KINETICS OF ENZYMATIC HYDROXYLATION OF PHENAZONE, OXIDATIVE O-DEMETHYLATION OF CODEINE AND N-DEMITHYLATION OF AMINOPHENAZONE BY RAT LIVER MICROSOMES

被引：23
|
作者：
NEUGEBAUER, A
SPLINTER, FK
HAFKE, D
KOBER, R
SCHIRLITZ, H
KLINGER, W
机构：
来源：
BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 07期
关键词：
D O I：
10.1016/0006-2952(69)90143-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：1559 / +
页数：1
相关论文
共 23 条
  • [21] Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways
    Dulac, Martin
    Sassi, Amor
    Nagarathinan, Citra
    Christen, Marie-Odile
    Dansette, Patrick M.
    Mansuy, Daniel
    Boucher, Jean-Luc
    DRUG METABOLISM AND DISPOSITION, 2018, 46 (10) : 1390 - 1395
  • [22] Cytochrome P4502D and -2C enzymes catalyze the oxidative N-demethylation of the parkinsonism-inducing substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rat liver microsomes
    Narimatsu, S
    Tachibana, M
    Masubuchi, Y
    Suzuki, T
    CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (01) : 93 - 98
  • [23] Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine: identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns
    Chung, WG
    Roh, HK
    Kim, HM
    Cha, YN
    CHEMICO-BIOLOGICAL INTERACTIONS, 1998, 113 (01) : 1 - 14
123