EXPRESSION OF MSL-2 CAUSES ASSEMBLY OF DOSAGE COMPENSATION REGULATORS ON THE X-CHROMOSOMES AND FEMALE LETHALITY IN DROSOPHILA

被引：259
作者：
KELLEY, RL
SOLOVYEVA, I
LYMAN, LM
RICHMAN, R
SOLOVYEV, V
KURODA, MI
机构：
[1] Howard Hughes Medical Institute Department, Cell Biology Baylor College of Medicine Houston
来源：
CELL | 1995年 / 81卷 / 06期
关键词：
D O I：
10.1016/0092-8674(95)90007-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Male-specific lethal-2 (msl-2) is a RING finger protein that is required for X chromosome dosage compensation in Drosophila males. Consistent with the formation of a dosage compensation protein complex, msl-2 colocalizes with the other MSL proteins on the male X chromosome and coimmunoprecipitates with msl-1 from male larval extracts. Ectopic expression of msl-2 in females results in the appearance of the other MSL dosage compensation regulators on the female X chromosomes and decreased female viability. We suggest that msl-2 RNA is the primary target of Sxl regulation in the dosage compensation pathway and present a speculative model for the regulation of two distinct modes of dosage compensation by Sxl.
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收藏
页码：867 / 877
页数：11
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