STEREOSELECTIVE INHIBITION BY D-ALANINE AND L-ALANINE OF PHENCYCLIDINE-INDUCED LOCOMOTOR STIMULATION IN THE RAT

被引：30

作者：

TANII, Y

NISHIKAWA, T

HASHIMOTO, A

TAKAHASHI, K

机构：

[1] NATL INST NEUROSCI,NCNP,DIV MENTAL DISORDER RES,4-1-1 OGAWA HIGASHI,KODAIRASHI,TOKYO 187,JAPAN

[2] NIPPON OIL & FATS CO LTD,TSUKUBA RES LAB,IBARAKI,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 563卷 / 1-2期

关键词：

PHENCYCLIDINE; N-METHYL-D-ASPARTATE RECEPTOR; STRYCHNINE-INSENSITIVE GLYCINE RECEPTOR; GLYCINE; D-ALANINE; L-ALANINE; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0006-8993(91)91546-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral injection of D-alanine, but not L-alanine, (10-100-mu-g per side for each amino acid) into the lateral ventricle reduced the increasing effect of phencyclidine (PCP, 10 mg/kg, given intraperitoneally) on locomotor activity in the rat in a dose dependent manner. This stereoselectivity agrees with the potency of these agents as agonists for the strychnine-insensitive glycine receptor in the N-methyl-D-aspartate receptor complex, suggesting that stimulation of the allosteric regulation site may antagonize the ability of PCP to produce hyperactivity.

引用

页码：281 / 284

页数：4

共 23 条

[21] GLYCINE BINDING TO RAT CORTEX AND SPINAL-CORD - BINDING CHARACTERISTICS AND PHARMACOLOGY REVEAL DISTINCT POPULATIONS OF SITES [J].