CLOMIPRAMINE AND AMITRIPTYLINE IN THE TREATMENT OF SEVERE PAIN

被引:72
作者
CARASSO, RL
YEHUDA, S
STREIFLER, M
机构
[1] BAR ILAN UNIV,DEPT PSYCHOL,PSYCHOPHARMACOL LAB,RAMAT GAN,ISRAEL
[2] ICHILOV HOSP,DEPT NEUROL,TEL AVIV,ISRAEL
关键词
Amitriptyline; Brain; 5-HT; Clomipramine; Postherpatic neuralgia; Tension headache; Trigeminal neuralgia;
D O I
10.3109/00207457909147672
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Clomipramine is the most potent 5-HT reuptake blockade agent among the antidepressants. A comparison between the effect of clomipramine and a less powerful 5-HT reuptake blockade agent (amitriptyline) could test the hypothesis that brain 5-HT is a mediator of pain sensation. Groups of patients of either sex, with pain indication of trigeminal neuralgia, tension headache or postherpatic neuralgia, received doses of clomipramine or amitriptyline in a single blind clinical experiment. The results after three months of treatment showed that clomipramine: (1) was better than amitriptyline in treating trigeminal neuralgia; (2) tended to be better in the treatment of tension headache; and (3) amitriptyline is better in treating postherpatic neuralgia. Clomipramine was better tolerated. The results support the hypothesis that in certain pain situations, clomipramine exerts a beneficial effect, not only because of its effect on the depression and anxiety level of the patient, but also via its effects on the 5-HT brain system. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:191 / 194
页数:4
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