Synthesis and Characterization of L-alanine based Poly(ester-amide)s

Novel biomaterials L-alanine based poly(ester-amide)s (PEAs) differing in the amide/ester ratio have been directly synthesized by direct melt copolycondensation of Adipic acid, L-alanine and various aliphatic and heterocyclic diols. PEAs were systematically characterized with intrinsic viscosity, FTIR, H-1-NMR, C-13-NMR, DSC and SEC measurements. The resulting copolymers are amorphous and present increasing glass transition temperatures at increasing L-Alanine contents. L-Alanine-PEAs proved to be materials having high molecular weights that could reach 41800 g/mol.