SYNTHESIS OF THE E-ISOMERS AND Z-ISOMERS OF THE ANTI-ESTROGEN TAMOXIFEN AND ITS METABOLITE, HYDROXYTAMOXIFEN, IN TRITIUM-LABELED FORM

被引：93

作者：

ROBERTSON, DW ^{[1
]}

KATZENELLENBOGEN, JA ^{[1
]}

机构：

[1] UNIV ILLINOIS,ROGER ADAMS LAB,DEPT CHEM,URBANA,IL 61801

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1982年 / 47卷 / 12期

关键词：

D O I：

10.1021/jo00133a030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：2387 / 2393

页数：7

共 42 条

[1] PREPARATION AND IDENTIFICATION OF CIS AND TRANS ISOMERS OF SUBSTITUTED TRIARYLETHYLENE [J].

BEDFORD, GR ;

RICHARDSON, DN .

NATURE, 1966, 212 (5063) :733-+

[2]

BORGNA JL, 1981, J BIOL CHEM, V256, P859

[3]

BORGNA JL, 1979, CR ACAD SCI D NAT, V289, P1141

[4] THE PREPARATION OF C-14 AND TRITIUM LABELED 1-[4-(2-DIMETHYLAMINO-ETHOXY)PHENYL]-1, 2-DIPHENYL-1-BUTENE [ICI-46,474, TAMOXIFEN (NOLVADEX)] AND THE SEPARATION OF CIS-TRANS ISOMERS .1. THE SYNTHESIS OF C-14-LABELED TAMOXIFEN (NOLVADEX) [J].

BURNS, J ;

RUTTER, D .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1982, 19 (02) :229-238

[5]

COHEN JB, 1914, J CHEM SOC, P501

[6] ANTIESTROGENIC AND ANTIFERTILITY COMPOUNDS .4. 1,1,2-TRIARYLALKAN-1-OLS AND 1,1,2-TRIARYLALK-1-ENES CONTAINING BASIC ETHER GROUPS [J].

COLLINS, DJ ;

HOBBS, JJ ;

EMMENS, CW .

JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (10) :952-&

[7] OXIDATIVE HYDROLYSIS OF 1,3-DITHIANE DERIVATIVES TO CARBONYL COMPOUNDS USING N-HALOSUCCINIMIDE REAGENTS [J].

COREY, EJ ;

ERICKSON, BW .

JOURNAL OF ORGANIC CHEMISTRY, 1971, 36 (23) :3553-&

[8]

EVANS EA, 1974, TRITIUM ITS COMPOUND, P327

[9]

EVANS EA, 1974, TRITIUM ITS COMPOUND, P321

[10] METABOLISM OF TAMOXIFEN (ICI 46,474) .1. LABORATORY-ANIMALS [J].

FROMSON, JM ;

PEARSON, S ;

BRAMAH, S .

XENOBIOTICA, 1973, 3 (11) :693-709

← 1 2 3 4 5 →