TRANSCRIPTIONAL REGULATION OF MULTIGENE LOCI - MULTILEVEL CONTROL

被引：184
作者：
DILLON, N
GROSVELD, F
机构：
来源：
TRENDS IN GENETICS | 1993年 / 9卷 / 04期
关键词：
D O I：
10.1016/0168-9525(93)90208-Y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent studies indicate that different levels of control operate within multigene loci. In addition to regulatory sequences immediately flanking the genes, there are also elements that act over long distances on more than one gene. Competition for these elements among genes can influence both the level and timing of gene expression during development.
引用
收藏
页码：134 / 137
页数：4
相关论文
共 49 条
[11]   DNASEL HYPERSENSITIVE SITE-1, SITE-2 AND SITE-3 OF THE HUMAN BETA-GLOBIN DOMINANT CONTROL REGION DIRECT POSITION-INDEPENDENT EXPRESSION [J].
FRASER, P ;
HURST, J ;
COLLIS, P ;
GROSVELD, F .
NUCLEIC ACIDS RESEARCH, 1990, 18 (12) :3503-3508
[12]   EACH HYPERSENSITIVE SITE OF THE HUMAN BETA-GLOBIN LOCUS-CONTROL REGION CONFERS A DIFFERENT DEVELOPMENTAL PATTERN OF EXPRESSION ON THE GLOBIN GENES [J].
FRASER, P ;
PRUZINA, S ;
ANTONIOU, M ;
GROSVELD, F .
GENES & DEVELOPMENT, 1993, 7 (01) :106-113
[13]   COHABITATION OF SCAFFOLD BINDING REGIONS WITH UPSTREAM ENHANCER ELEMENTS OF 3 DEVELOPMENTALLY REGULATED GENES OF DROSOPHILA-MELANOGASTER [J].
GASSER, SM ;
LAEMMLI, UK .
CELL, 1986, 46 (04) :521-530
[14]  
GIGLIONI B, 1984, EMBO J, V11, P2641
[15]   HUMAN CD2 3'-FLANKING SEQUENCES CONFER HIGH-LEVEL, T-CELL-SPECIFIC, POSITION-INDEPENDENT GENE-EXPRESSION IN TRANSGENIC MICE [J].
GREAVES, DR ;
WILSON, FD ;
LANG, G ;
KIOUSSIS, D .
CELL, 1989, 56 (06) :979-986
[16]   POSITION-INDEPENDENT, HIGH-LEVEL EXPRESSION OF THE HUMAN BETA-GLOBIN GENE IN TRANSGENIC MICE [J].
GROSVELD, F ;
VANASSENDELFT, GB ;
GREAVES, DR ;
KOLLIAS, G .
CELL, 1987, 51 (06) :975-985
[17]   A NEW HOMEOTIC MUTATION IN THE DROSOPHILA BITHORAX COMPLEX REMOVES A BOUNDARY SEPARATING 2 DOMAINS OF REGULATION [J].
GYURKOVICS, H ;
GAUSZ, J ;
KUMMER, J ;
KARCH, F .
EMBO JOURNAL, 1990, 9 (08) :2579-2585
[18]   IMPORTANCE OF GLOBIN GENE ORDER FOR CORRECT DEVELOPMENTAL EXPRESSION [J].
HANSCOMBE, O ;
WHYATT, D ;
FRASER, P ;
YANNOUTSOS, N ;
GREAVES, D ;
DILLON, N ;
GROSVELD, F .
GENES & DEVELOPMENT, 1991, 5 (08) :1387-1394
[19]   STRUCTURE AND FUNCTION OF THE MURINE BETA-GLOBIN LOCUS-CONTROL REGION 5' HS-3 [J].
HUG, BA ;
MOON, AM ;
LEY, TJ .
NUCLEIC ACIDS RESEARCH, 1992, 20 (21) :5771-5778
[20]   A POSITION-EFFECT ASSAY FOR BOUNDARIES OF HIGHER-ORDER CHROMOSOMAL DOMAINS [J].
KELLUM, R ;
SCHEDL, P .
CELL, 1991, 64 (05) :941-950
12345