TRANSCRIPTIONAL REGULATION OF MULTIGENE LOCI - MULTILEVEL CONTROL

被引：184
作者：
DILLON, N
GROSVELD, F
机构：
来源：
TRENDS IN GENETICS | 1993年 / 9卷 / 04期
关键词：
D O I：
10.1016/0168-9525(93)90208-Y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent studies indicate that different levels of control operate within multigene loci. In addition to regulatory sequences immediately flanking the genes, there are also elements that act over long distances on more than one gene. Competition for these elements among genes can influence both the level and timing of gene expression during development.
引用
收藏
页码：134 / 137
页数：4
相关论文
共 49 条
[1]   EXPRESSION OF A BETA-GLOBIN GENE IS ENHANCED BY REMOTE SV40 DNA-SEQUENCES [J].
BANERJI, J ;
RUSCONI, S ;
SCHAFFNER, W .
CELL, 1981, 27 (02) :299-308
[2]   A SINGLE POINT MUTATION IS THE CAUSE OF THE GREEK FORM OF HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN [J].
BERRY, M ;
GROSVELD, F ;
DILLON, N .
NATURE, 1992, 358 (6386) :499-502
[3]   TISSUE SPECIFIC AND POSITION INDEPENDENT EXPRESSION OF THE COMPLETE GENE DOMAIN FOR CHICKEN LYSOZYME IN TRANSGENIC MICE [J].
BONIFER, C ;
VIDAL, M ;
GROSVELD, F ;
SIPPEL, AE .
EMBO JOURNAL, 1990, 9 (09) :2843-2848
[4]   DEVELOPMENTAL REGULATION OF BETA-GLOBIN GENE SWITCHING [J].
CHOI, ORB ;
ENGEL, JD .
CELL, 1988, 55 (01) :17-26
[5]   CHROMOSOMAL LOOP ANCHORAGE OF THE KAPPA IMMUNOGLOBULIN GENE OCCURS NEXT TO THE ENHANCER IN A REGION CONTAINING TOPOISOMERASE-II SITES [J].
COCKERILL, PN ;
GARRARD, WT .
CELL, 1986, 44 (02) :273-282
[6]  
DEVILLIERS J, 1982, COLD SPRING HARB SYM, V47, P911
[7]   HUMAN GAMMA-GLOBIN GENES SILENCED INDEPENDENTLY OF OTHER GENES IN THE BETA-GLOBIN LOCUS [J].
DILLON, N ;
GROSVELD, F .
NATURE, 1991, 350 (6315) :252-254
[8]   GAMMA-DELTA-BETA-THALASSEMIA DUE TO A DENOVO MUTATION DELETING THE 5' BETA-GLOBIN GENE ACTIVATION-REGION HYPERSENSITIVE SITES [J].
DRISCOLL, MC ;
DOBKIN, CS ;
ALTER, BP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) :7470-7474
[9]   MODULARITY IN PROMOTERS AND ENHANCERS [J].
DYNAN, WS .
CELL, 1989, 58 (01) :1-4
[10]   A DELETION OF THE HUMAN BETA-GLOBIN LOCUS ACTIVATION REGION CAUSES A MAJOR ALTERATION IN CHROMATIN STRUCTURE AND REPLICATION ACROSS THE ENTIRE BETA-GLOBIN LOCUS [J].
FORRESTER, WC ;
EPNER, E ;
DRISCOLL, MC ;
ENVER, T ;
BRICE, M ;
PAPAYANNOPOULOU, T ;
GROUDINE, M .
GENES & DEVELOPMENT, 1990, 4 (10) :1637-1649
12345