PROTEIN OXIDATION AND AGING

被引：1556
作者：
STADTMAN, ER
机构：
[1] Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda
来源：
SCIENCE | 1992年 / 257卷 / 5074期
关键词：
D O I：
10.1126/science.1355616
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A number of systems that generate oxygen free radicals catalyze the oxidative modification of proteins. Such modifications mark enzymes for degradation by cytosolic neutral alkaline proteases. Protein oxidation contributes to the pool of damaged enzymes, which increases in size during aging and in various pathological states. The age-related increase in amounts of oxidized protein may reflect the age-dependent accumulation of unrepaired DNA damage that, in a random manner, affects the concentrations or activities of numerous factors that govern the rates of protein oxidation and the degradation of oxidized protein.
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页码：1220 / 1224
页数：5
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