SINGLE PHOTON-EMISSION COMPUTED-TOMOGRAPHY USING TC-99M-HMPAO IN THE ROUTINE EVALUATION OF ALZHEIMERS-DISEASE

被引：27
作者：
HURWITZ, TA
AMMANN, W
CHU, D
CLARK, C
HOLDEN, J
BROWNSTONE, R
机构：
[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,VANCOUVER V6T 1W5,BC,CANADA
[2] UNIV BRITISH COLUMBIA,DEPT NUCL MED,VANCOUVER V6T 1W5,BC,CANADA
[3] UNIV BRITISH COLUMBIA,DEPT PATHOL,VANCOUVER V6T 1W5,BC,CANADA
[4] UNIV BRITISH COLUMBIA,DEPT PHYSIOL,VANCOUVER V6T 1W5,BC,CANADA
来源：
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 18卷 / 01期
关键词：
D O I：
10.1017/S0317167100031292
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Regional cerebral blood flow was studied in 7 patients with clinically suspected Alzheimer's disease and 10 normal controls by single photon computed emission tomography (SPECT) using HM-PAO. All patients with Alzheimer's disease and no controls had parietal lobe hypoperfusion which was usually bilateral. In patients with more severe dementia hypoperfusion extended into the frontal lobes. Parietal lobe hypoperfusion corresponds to parietal lobe degeneration which is the one of the first neocortical regions to show the typical degenerative changes of Alzheimer's disease. SPECT with HM-PAO is a non-invasive investigation available in most nuclear medicine departments and complements existing tests in the routine evaluation of patients presenting with dementia.
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页码：59 / 62
页数：4
相关论文
共 15 条
  • [1] BARON JC, 1982, J NUCL MED, V23, P391
  • [2] REGIONAL PATTERN OF DEGENERATION IN ALZHEIMERS-DISEASE - NEURONAL LOSS AND HISTOPATHOLOGICAL GRADING
    BRUN, A
    ENGLUND, E
    [J]. HISTOPATHOLOGY, 1981, 5 (05) : 549 - 564
  • [3] CHASE TN, 1984, ANN NEUROL, V15, pS170
  • [4] BRAIN METABOLISM AS MEASURED WITH POSITRON EMISSION TOMOGRAPHY - SERIAL ASSESSMENT IN A PATIENT WITH FAMILIAL ALZHEIMERS-DISEASE
    CUTLER, NR
    HAXBY, JV
    DUARA, R
    GRADY, CL
    MOORE, AM
    PARISI, JE
    WHITE, J
    HESTON, L
    MARGOLIN, RM
    RAPOPORT, SI
    [J]. NEUROLOGY, 1985, 35 (11) : 1556 - 1561
  • [5] POSITRON EMISSION TOMOGRAPHY IN ALZHEIMERS-DISEASE
    DUARA, R
    GRADY, C
    HAXBY, J
    SUNDARAM, M
    CUTLER, NR
    HESTON, L
    MOORE, A
    SCHLAGETER, N
    LARSON, S
    RAPOPORT, SI
    [J]. NEUROLOGY, 1986, 36 (07) : 879 - 887
  • [6] FUNCTIONAL IMAGING OF THE BRAIN
    ELL, PJ
    JARRITT, PH
    COSTA, DC
    CULLUM, ID
    LUI, D
    [J]. SEMINARS IN NUCLEAR MEDICINE, 1987, 17 (03) : 214 - 229
  • [7] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN
    FOLSTEIN, MF
    FOLSTEIN, SE
    MCHUGH, PR
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) : 189 - 198
  • [8] DIFFERENTIAL-DIAGNOSIS IN DEMENTIA USING THE CEREBRAL BLOOD-FLOW AGENT TC-99M HMPAO - A SPECT STUDY
    GEMMELL, HG
    SHARP, PF
    BESSON, JAO
    CRAWFORD, JR
    EBMEIER, KP
    DAVIDSON, J
    SMITH, FW
    [J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1987, 11 (03) : 398 - 402
  • [9] A NEW CLINICAL-SCALE FOR THE STAGING OF DEMENTIA
    HUGHES, CP
    BERG, L
    DANZIGER, WL
    COBEN, LA
    MARTIN, RL
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1982, 140 (JUN) : 566 - 572
  • [10] SINGLE PHOTON-EMISSION COMPUTED-TOMOGRAPHY IN ALZHEIMERS-DISEASE - ABNORMAL IOFETAMINE-I 123 UPTAKE REFLECTS DEMENTIA SEVERITY
    JOHNSON, KA
    HOLMAN, BL
    MUELLER, SP
    ROSEN, TJ
    ENGLISH, R
    NAGEL, JS
    GROWDON, JH
    [J]. ARCHIVES OF NEUROLOGY, 1988, 45 (04) : 392 - 396
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