Genetic identification and serological evaluation of commercial inactivated foot-and-mouth disease virus vaccine in pigs

被引：1

作者：

Je, Sang H. ^{[1
]}

Kwon, Taeyong ^{[1
]}

Yoo, Sung J. ^{[1
]}

Lee, Dong-Uk ^{[1
,3
]}

Seo, Sang Won ^{[2
]}

Byun, Jeong J. ^{[1
]}

Shin, Jeong Y. ^{[1
]}

Lyoo, Young S. ^{[1
]}

机构：

[1] Konkuk Univ, Coll Vet Med, 120 Neungdong Ro, Seoul 05029, South Korea

[2] Hipra Korea Inc, Seongnam, South Korea

[3] Choongang Vaccine Lab, Daejeon, South Korea

来源：

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH | 2018年 / 7卷 / 02期

关键词：

Antibody formation; Foot-and-mouth disease; Real-time polymerase chain reaction; Vaccines;

D O I：

10.7774/cevr.2018.7.2.139

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccination is considered a frequently used tool to prevent and control foot-and-mouth disease (FMD). However, the effectiveness of conventional FMD virus (FMDV) vaccines in pigs has been controversial because the massive prophylactic vaccination could not elicit proper immune response nor prevent the broad spread of FMD outbreak, mainly in pig farms, in South Korea during outbreaks of 2014. In addition, there has been little information on the efficacy of inactivated, high potency, multivalent, oil-based FMDV vaccine in pigs, because an evaluation of FMDV vaccines had been mainly carried out using cattle. In this study, we evaluated the genetic identification of commercial inactivated FMDV vaccine and monitored the immune responses in pigs under the field condition. Results implied that it contained three different serotypes with a high level of antigen payload. However, serological results showed low mean percentage of inhibition, and positive rate reached its peak at 6-week post-vaccination, indicating current FMDV vaccine need to improve for a prophylactic vaccination policy in pigs. Therefore, there is an imperative need to develop FMDV vaccine that can provide rapid and long-lasting protective immunity in pigs.

引用

页码：139 / 144

页数：6

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