Abdominal Aortic Aneurysm: Evolving Controversies and Uncertainties

被引：35

作者：

Carino, Davide ^{[1
]}

Sarac, Timur P. ^{[2
]}

Ziganshin, Bulat A. ^{[1
,3
]}

Elefteriades, John A. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Aort Inst Yale New Haven, 789 Howard Ave,Clin Bldg CB317, New Haven, CT 06519 USA

[2] Yale Univ, Sch Med, Dept Surg, Sect Vasc & Endovasc Surg, New Haven, CT 06510 USA

[3] Kazan State Med Univ, Dept Surg Dis 2, Kazan, Russia

来源：

INTERNATIONAL JOURNAL OF ANGIOLOGY | 2018年 / 27卷 / 02期

关键词：

abdominal aortic aneurysm; AAA; risk factors; animal models; indication for AAA surgery; rupture AAA; endovascular aortic repair;

D O I：

10.1055/s-0038-1657771

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Abdominal aortic aneurysm (AAA) is defined as a permanent dilatation of the abdominal aorta that exceeds 3 cm. Most AAAs arise in the portion of abdominal aorta distal to the renal arteries and are defined as infrarenal. Most AAAs are totally asymptomatic until catastrophic rupture. The strongest predictor of AAA rupture is the diameter. Surgery is indicated to prevent rupture when the risk of rupture exceeds the risk of surgery. In this review, we aim to analyze this disease comprehensively, starting from an epidemiological perspective, exploring etiology and pathophysiology, and concluding with surgical controversies. We will pursue these goals by addressing eight specific questions regarding AAA: (1) Is the incidence of AAA increasing? (2) Are ultrasound screening programs for AAA effective? (3) What causes AAA: Genes versus environment? (4) Animal models: Are they really relevant? (5) What pathophysiology leads to AAA? (6) Indications for AAA surgery: Are surgeons over-eager to operate? (7) Elective AAA repair: Open or endovascular? (8) Emergency AAA repair: Open or endovascular?

引用

页码：58 / 80

页数：23

共 252 条

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