EVIDENCE AGAINST A ROLE FOR METABOTROPIC GLUTAMATE RECEPTORS IN MOSSY FIBER LTP - THE USE OF MUTANT MICE AND PHARMACOLOGICAL ANTAGONISTS

被引：38
作者：
HSIA, AY
SALINI, PA
CASTILLO, PE
AIBA, A
ABELIOVICH, A
TONEGAWA, S
NICOLL, RA
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT CELLULAR & MOLEC PHARMACOL,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,GRAD PROGRAM NEUROSCI,SAN FRANCISCO,CA 94143
[4] MIT,HOWARD HUGHES MED INST,CTR LEARNING & MEMORY,CAMBRIDGE,MA 02139
来源：
NEUROPHARMACOLOGY | 1995年 / 34卷 / 11期
关键词：
LONG-TERM POTENTIATION (LTP); METABOTROPIC GLUTAMATE RECEPTORS (MGLURS); MOSSY FIBERS; HIPPOCAMPUS; PROTEIN KINASE C;
D O I：
10.1016/0028-3908(95)00115-M
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have used a number of approaches to address a possible role of metabotropic glutamate receptors (mGluRs) in messy fiber long-term potentiation (LTP) in the hippocampus. We have used two types of mutant mice-one lacking the mGluR1 subtype of receptor and one lacking the gamma isoform of protein kinase C. In neither type of mouse did we find any alteration in the magnitude of messy fiber LTP. We next examined whether mGluRs might modulate the magnitude and/or threshold for the induction of messy fiber LTP. In these experiments we used tetani that were either just subthreshold or just suprathreshold for generating LTP. The mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine [(+)MCPG] did not convert a subthreshold tetanus into a suprathreshold tetanus, nor did (+)MCPG have any effect on the small amount of LTP that was generated by a just suprathreshold tetanus. Based on our studies, we have been unable to identify a role for mGluRs in messy fiber LTP.
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页码：1567 / 1572
页数：6
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