CHANGES IN THE FATTY-ACID COMPOSITION OF STORED ERYTHROCYTES FROM SHEEP OF DIFFERENT AGES

被引：5

作者：

FERNANDEZ, A ^{[1
]}

SANCHEZYAGUE, J ^{[1
]}

MARTINVALMASEDA, EM ^{[1
]}

FELIPE, A ^{[1
]}

CABEZAS, JA ^{[1
]}

LLANILLO, M ^{[1
]}

机构：

[1] UNIV SALAMANCA,FAC BIOL,DEPT BIOQUIM & BIOL MOLEC,E-37007 SALAMANCA,SPAIN

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1993年 / 71卷 / 03期

关键词：

AGING; STORAGE; FATTY ACIDS; LIPID PEROXIDATION; ERYTHROCYTE MEMBRANE (SHEEP);

D O I：

10.1016/0047-6374(93)90083-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study examined the profile in sheep erythrocyte fatty acids from animals of different ages during storage at 4 degrees C in a nutritive medium for up to 6 days. The changes found in the fatty acyl profile were a decrease (P<0.01) in the percentage of arachidonic acid and an increase (P<0.01) in the percentage of minor fatty acids (representing < 2% in each case; 20:2, 22:0 and 22:1) with respect to fresh erythrocytes in all age groups. However, the saturated/unsaturated ratios and unsaturated index started almost constant in all cases. The changes observed occurred after 24-48 h of storage, with significant increases (P<0.01) in the fluorescence detected in the lipid extracts from stored erythrocytes during this period. The above findings suggest peroxidative damage and changes in the erythrocyte lipid membrane during storage.

引用

页码：189 / 198

页数：10

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