ENANTIOSELECTIVE CONJUGATE REDUCTION OF ALPHA,BETA-UNSATURATED CARBOXAMIDES WITH SEMICORRIN COBALT CATALYSTS

被引：50

作者：

VONMATT, P ^{[1
]}

PFALTZ, A ^{[1
]}

机构：

[1] UNIV BASEL,INST ORGAN CHEM,S JOHANNS RING 19,CH-4056 BASEL,SWITZERLAND

来源：

TETRAHEDRON-ASYMMETRY | 1991年 / 2卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)86123-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral semicorrin cobalt complexes, prepared in situ from cobalt(II) chloride and the free ligands, are efficient, highly enantioselective catalysts for the conjugate reduction of alpha,beta-unsaturated carboxamides with sodium borohydride. Enantiomeric excesses of up to 99 %, essentially quantitative yields, and high substrate/catalyst ratios (1 000 - 10 000:1) are attractive attributes of this catalytic process.

引用

页码：691 / 700

页数：10

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