NEURAL MECHANISMS UNDERLYING THE ACTION OF PRIMER PHEROMONES IN MICE

被引:44
作者
LI, CS
KABA, H
SAITO, H
SETO, K
机构
[1] Department of Physiology, Kochi Medical School, Nankoku, Kochi
关键词
D O I
10.1016/0306-4522(90)90019-Z
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Our electrophysiological experiments in female mice have provided evidence that electrical stimulation of the accessory olfactory bulb orthodromically excites a subpopulation of tuberoinfundibular arcuate neurons by way of the amygdala. The present study shows that half of such neurons are identified as dopaminergic by examining the effectiveness of infusing 6-hydroxydopamine and 5,7-dihydroxy-tryptamine locally into the median eminence in blocking their antidromic response. Further attention is focused on excitatory amino acid receptors within the amygdala and the amygdaloid pathway that mediate the accessory bulb-induced excitation of tuberoinfundibular arcuate neurons. The excitatory transmission was reversibly blocked by intra-amygdala infusion (3 nmol) of the excitatory amino acid antagonists kynurenic acid, d,l-2-amino-5-phosphonovalerate, γ-d-glutamylaminomethylsulphonate and d,l-2-amino-4-phosphonobutyrate. Intra-amygdala infusions (3 nmol) of N-methyl-d-aspartate and kainate markedly enhanced the firing activity of tuberoinfundibular arcuate neurons with excitatory inputs from the accessory bulb, whereas similar infusions of quisqualate were without effect. Intra-stria terminalis infusions of the local anaesthetic lignocaine completely abolished the excitatory transmission in all the cells tested. Furthermore, tuberoinfundibular arcuate neurons stimulated from the accessory bulb were also orthodromically stimulated from the stria terminalis with a shorter latency. These studies demonstrate that the projections of the accessory olfactory bulb activate excitatory amino acid receptors within the amygdala and subsequently the stria terminalis route, thereby causing excitation of tuberoinfundibular dopaminergic arcuate neurons. This functional pathway can account for the reproductive effects so far described as a consequence of vomeronasal chemoreception. © 1990.
引用
收藏
页码:773 / 778
页数:6
相关论文
共 28 条
[1]   EVIDENCE FOR NOREPINEPHRINE-MEDIATED COLLATERAL INHIBITION OF LOCUS COERULEUS NEURONS [J].
AGHAJANIAN, GK ;
CEDARBAUM, JM ;
WANG, RY .
BRAIN RESEARCH, 1977, 136 (03) :570-577
[2]  
BELLRINGER JF, 1980, J REPROD FERTIL, V59, P223, DOI 10.1530/jrf.0.0590223
[3]   SELECTIVE IMMUNOCYTOCHEMICAL STAINING OF MITRAL CELLS IN RAT OLFACTORY-BULB WITH AFFINITY PURIFIED ANTIBODIES AGAINST N-ACETYL-ASPARTYL-GLUTAMATE [J].
BLAKELY, RD ;
ORYLAVOLLEE, L ;
GRZANNA, R ;
KOLLER, KJ ;
COYLE, JT .
BRAIN RESEARCH, 1987, 402 (02) :373-378
[4]  
BUNNEY BS, 1979, NEUROBIOLOGY DOPAMIN, P417
[5]   EFFECTS OF EXCITATORY AMINO-ACID ANTAGONISTS ON EVOKED AND SPONTANEOUS EXCITATORY POTENTIALS IN GUINEA-PIG HIPPOCAMPUS [J].
COTMAN, CW ;
FLATMAN, JA ;
GANONG, AH ;
PERKINS, MN .
JOURNAL OF PHYSIOLOGY-LONDON, 1986, 378 :403-415
[6]   PROJECTION FIELD OF STRIA TERMINALIS IN RAT-BRAIN - EXPERIMENTAL STUDY [J].
DEOLMOS, JS ;
INGRAM, WR .
JOURNAL OF COMPARATIVE NEUROLOGY, 1972, 146 (03) :303-+
[7]   L(+)-2-AMINO-4-PHOSPHONOBUTYRATE INHIBITS THE RELEASE OF BOTH GLUTAMATE AND DYNORPHIN FROM GUINEA-PIG BUT NOT RAT HIPPOCAMPAL MOSSY FIBER SYNAPTOSOMES [J].
GANNON, RL ;
BATY, LT ;
TERRIAN, DM .
BRAIN RESEARCH, 1989, 495 (01) :151-155
[8]   ANTIDROMIC IDENTIFICATION OF DOPAMINERGIC AND OTHER OUTPUT NEURONS OF RAT SUBSTANTIA NIGRA [J].
GUYENET, PG ;
AGHAJANIAN, GK .
BRAIN RESEARCH, 1978, 150 (01) :69-84
[9]   NEUROCHEMISTRY OF THE VERTEBRATE OLFACTORY-BULB [J].
HALASZ, N ;
SHEPHERD, GM .
NEUROSCIENCE, 1983, 10 (03) :579-619
[10]  
KABA H, 1986, EXP BRAIN RES, V63, P369