ENHANCEMENT OF ANTIBODY-RESPONSES TO INFLUENZA-B VIRUS HEMAGGLUTININ BY USE OF A NEW ADJUVANT FORMULATION

被引：36

作者：

BYARS, NE ^{[1
]}

ALLISON, AC ^{[1
]}

HARMON, MW ^{[1
]}

KENDAL, AP ^{[1
]}

机构：

[1] CTR DIS CONTROL, CTR INFECT DIS, DIV VIRAL DIS, INFLUENZA BRANCH, ATLANTA, GA 30333 USA

来源：

VACCINE | 1990年 / 8卷 / 01期

关键词：

adjuvant; antibody response; Influenza B virus haemagglutinin;

D O I：

10.1016/0264-410X(90)90177-N

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice and guinea pigs were immunized with the haemagglutinin (HA) of influenza B-USSR/100 virus, either in Syntex Adjuvant Formulation-1 (SAF-1) or in saline. Antibody titres were determined by ELISA, haemagglutination inhibition and virus neutralization. Animals immunized with HA in SAF-1 had significantly higher antibody titres than did animals immunized with HA in saline. Both 3-week-old and 13 1 2-month-old mice had greater and more uniform antibody responses to HA in SAF-1 than to HA in saline. © 1990.

引用

页码：49 / 56

页数：8

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