PRAZIQUANTEL-INDUCED EXPOSURE OF SCHISTOSOMA-MANSONI ALKALINE-PHOSPHATASE - DRUG-ANTIBODY SYNERGY WHICH ACTS PREFERENTIALLY AGAINST FEMALE WORMS

被引：32
作者：
FALLON, PG
SMITH, P
NICHOLLS, T
MODHA, J
DOENHOFF, MJ
机构：
[1] School of Biological Sciences, University of Wales, Bangor, Gwynedd
来源：
PARASITE IMMUNOLOGY | 1994年 / 16卷 / 10期
基金：
英国惠康基金;
关键词：
SCHISTOSOMA-MANSONI; PRAZIQUANTEL; TEGUMENTAL DAMAGE; ALKALINE PHOSPHATASE; FEMALE MORTALITY;
D O I：
10.1111/j.1365-3024.1994.tb00307.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The efficacy of praziquantel-treatment of murine Schistosoma mansoni-infections can be enhanced by concurrent administration of rabbit anti-sera with specificity for parasite antigens. Monospecific rabbit serum raised against S. mansoni worm alkaline phosphatase, that was reactive with the enzyme an the drug-treated female surface, was found to significantly and preferentially increase the mortality of female worms by PZQ. Immunoglobulins purified from the anti-alkaline phosphatase antiserum inhibited 54% of schistosome alkaline phosphatase enzymatic activity on the surface of praziquantel-treated worms. We propose that synergistic antibody-mediated death of drug-damaged worms is a consequence of the inhibition of drug-exposed alkaline phosphatase on the female worm surface by passively transferred antibody.
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收藏
页码：529 / 535
页数：7
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