SYNERGISM BETWEEN CYTOTOXIN-P4 FROM THE SNAKE-VENOM OF NAJA-NIGRICOLLIS-NIGRICOLLIS AND VARIOUS PHOSPHOLIPASES

被引：12

作者：

CHAIMMATYAS, A ^{[1
]}

BORKOW, G ^{[1
]}

OVADIA, M ^{[1
]}

机构：

[1] TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT ZOOL,IL-69978 TEL AVIV,ISRAEL

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1995年 / 110卷 / 01期

关键词：

SNAKE VENOM; CYTOTOXIN; PHOSPHOLIPASE A; SYNERGISM;

D O I：

10.1016/0305-0491(94)00130-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synergism between the lytic activity of cytotoxin P4 isolated from the venom of Naja nigricollis nigricollis and various phospholipases (PLA) is demonstrated. The highest synergistic activity was obtained with one of the basic phospholipases found in the same venom. It was also shown between cytotoxin P4 and heterologous elapid and viperid snake phospholipases. Moreover, remarkable synergism was also demonstrated between cytotoxin P4 and bee venom PLA(2) or porcine pancreatic PLA(2). However, the phospholipase fractions of Vipera palestinae and the bovine pancreas PLA(2) had no synergistic effect.

引用

页码：83 / 89

页数：7

共 27 条

[1] BORKOW G, 1991, BIOCHEM INT, V25, P261
[2] BORKOW G, 1992, FEMS MICROBIOL IMMUN, V105, P139
[3] BORKOW G, 1993, J NAT TOXINS, V2, P199
[4] INVIVO SYNERGY OF CARDIOTOXIN AND PHOSPHOLIPASE-A2 FROM THE ELAPID SNAKE NAJA-MOSSAMBICA-MOSSAMBICA
BOUGIS, PE
MARCHOT, P
ROCHAT, H
[J]. TOXICON, 1987, 25 (04) : 427 - 431
[5] CHAIMMATYAS A, 1991, BIOCHEM INT, V24, P415
[6] CYTOTOXIC ACTIVITY OF VARIOUS SNAKE-VENOMS ON MELANOMA, B16F10 AND CHONDROSARCOMA
CHAIMMATYAS, A
OVADIA, M
[J]. LIFE SCIENCES, 1987, 40 (16) : 1601 - 1607
[7] CHAIMMATYAS A, 1993, BIOTECHNOL APPL BIOC, V17, P31
[8] COBRA VENOM CARDIOTOXIN (CYTOTOXIN) ISOFORMS AND NEUROTOXIN - COMPARATIVE POTENCY OF PROTEIN-KINASE-C INHIBITION AND CANCER CELL CYTOTOXICITY AND MODES OF ENZYME-INHIBITION
CHIOU, SH
RAYNOR, RL
ZHENG, B
CHAMBERS, TC
KUO, JF
[J]. BIOCHEMISTRY, 1993, 32 (08) : 2062 - 2067
[9] COMPARISON OF A RELATIVELY TOXIC PHOSPHOLIPASE-A2 FROM NAJA-NIGRICOLLIS SNAKE-VENOM WITH THAT OF A RELATIVELY NON-TOXIC PHOSPHOLIPASE-A2 FROM HEMACHATUS-HAEMACHATUS SNAKE-VENOM .1. ENZYMATIC-ACTIVITY ON FREE AND MEMBRANE-BOUND SUBSTRATES
CONDREA, E
YANG, CC
ROSENBERG, P
[J]. BIOCHEMICAL PHARMACOLOGY, 1980, 29 (11) : 1555 - 1563
[10] HEMOLYSIS + SPLITTING OF HUMAN ERYTHROCYTE PHOSPHOLIPIDS BY SNAKE VENOMS
CONDREA, E
DEVRIES, A
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 84 (01) : 60 - &

← 1 2 3 →