A NOVEL EFFICIENT SYNTHESIS OF 1-ETHOXYVINYL ESTERS AND THEIR USE IN ACYLATION OF AMINES AND ALCOHOLS - SYNTHESIS OF WATER-SOLUBLE OXAUNOMYCIN DERIVATIVES

被引：0

作者：

KITA, Y

MAEDA, H

OMORI, K

OKUNO, T

TAMURA, Y

机构：

来源：

SYNLETT | 1993年 / 04期

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暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

I-Ethoxyvinyl esters (la-i), prepared by the addition of carboxylic acids to ethoxyacetylene in the presence of a catalytic amount of [RuCl2(p-cymene)]2, react with amines (3a-d) and alcohols (5a-e) to give the corresponding N- and 0-acylated compounds (4a-1 and 6a-f) in high yields. Application of this method to the synthesis of water-soluble oxaunomycin derivatives (9a,b) is also described.

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页码：273 / 274

页数：2

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