MOLECULAR EPIDEMIOLOGY OF ENVELOPE GLYCOPROTEIN-H OF HUMAN CYTOMEGALOVIRUS

被引：98
作者：
CHOU, SW
机构：
[1] VET ADM MED CTR, MED SERV, PORTLAND, OR 97207 USA
[2] VET ADM MED CTR, RES SERV, PORTLAND, OR 97207 USA
[3] OREGON HLTH SCI UNIV, DIV INFECT DIS, PORTLAND, OR 97201 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 1992年 / 166卷 / 03期
关键词：
D O I：
10.1093/infdis/166.3.604
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complete envelope glycoprotein H (gH) coding sequences of 10 clinical strains of cytomegalovirus (CMV) were determined and compared with those of laboratory strains AD169 and Towne. Their translated peptide sequences segregated into two groups, exemplified by AD169 and Towne. Peptide variation was mostly group-specific and was clustered in the first 37 amino acids, including the signal sequence; in the rest of the molecule, there were scattered amino acid substitutions, usually in single residues. Compared with CMV envelope glycoprotein B, gH is more highly conserved among strains and may be expected to have limited immunologic diversity.
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页码：604 / 607
页数：4
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