DISTINCTIVE PHARMACOLOGICAL ACTIVITIES OF Eclipta alba AND IT'S COUMESTAN WEDELOLACTONE

被引：3

作者：

Balakrishnan, Purushothaman ^{[1
,2
]}

Sekar, Gowtham Kumar ^{[1
]}

Ramalingam, Prasanna Srinivasan ^{[1
]}

Nagarasan, Suganthi ^{[2
]}

Murugesan, Vasumathi ^{[2
]}

Shanmugam, Kumaran ^{[1
]}

机构：

[1] Periyar Maniammai Inst Sci & Technol, Dept Biotechnol, Thanjavur 613403, Tamil Nadu, India

[2] Periyar Maniammai Inst Sci & Technol, Periyar Technol Business Incubator, TANBIO R&D Solut, 213,1st Floor, Thanjavur 613403, Tamil Nadu, India

来源：

INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 5卷 / 04期

关键词：

Eclipta alba; Coumestan; Wedelolactone; Hepatoprotective; anticancer; anti-fibrotic;

D O I：

10.5281/zenodo.1231062

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eclipta alba Linn. (Eclipta prostrata) is a perennial herb belongs to the family Asteraceae which is widespread all over the world especially in south Asian countries like India, Nepal, China and Thailand. Because of its numerous pharmacological activities, it is used in Siddha, Unani and Ayurveda to treat skin infections, headache, toothache and other such ailments. It possess anti-inflammatory, anti-fibrotic, anti-osteoporotic, anti-cancer and hepatoprotective activities due to the phytochemicals like dimethyl wedelolactone and wedelolactone present in it. The coumestan wedelolactone has potent activity against human pathogens like Bacillus subtilis, Pseudomonas aeruginosa, E.coli and Salmonella typhi. We pen down this reviewto investigate the predominant pharmacological activities of coumestan wedelolactone.

引用

页码：2996 / 3002

页数：7

共 44 条

[1]

[Anonymous], 1997, TOXICON, V37, P199

[2]

Aruna AP, 2017, INDOAMERICAN J PHARM, V7

[3]

Balakrishnan P, 2015, J CHEM PHARM RES, V1, P507

[4]

Benes Petr, 2012, ENIVIRONMENTAL MOL M

[5] Total synthesis of demethylwedelolactone and wedelolactone by Cu-mediated/Pd(0)-catalysis and oxidative-cyclization [J].

Chang, Chia-Fu ;

Yang, Ling-Yi ;

Chang, Shiao-Wei ;

Fang, Yu-Ting ;

Lee, Yean-Jang .

TETRAHEDRON, 2008, 64 (17) :3661-3666

[6] Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus [J].

Christybapita, D. ;

Divyagnaneswari, M. ;

Michael, R. Dinakaran .

FISH & SHELLFISH IMMUNOLOGY, 2007, 23 (04) :840-852

[7] Anti-Inflammatory Gallic Acid and Wedelolactone Are G Protein-Coupled Receptor-35 Agonists [J].

Deng, Huayun ;

Fang, Ye .

PHARMACOLOGY, 2012, 89 (3-4) :211-219

[8]

Elisa Pocas SC, 2006, BIOCH MED CHEM, V14, P7962

[9] Simultaneous extraction, identification and quantification of phenolic compounds in Eclipta prostrata using microwave-assisted extraction combined with HPLC-DAD-ESI-MS/MS [J].

Fang, Xinsheng ;

Wang, Jianhua ;

Hao, Jifu ;

Li, Xueke ;

Guo, Ning .

FOOD CHEMISTRY, 2015, 188 :527-536

[10] Optimization of ultrasonic-assisted extraction of wedelolactone and antioxidant polyphenols from Eclipta prostrate L using response surface methodology [J].

Fang, Xinsheng ;

Wang, Jianhua ;

Wang, Yingzi ;

Li, Xueke ;

Zhou, Hongying ;

Zhu, Lixiang .

SEPARATION AND PURIFICATION TECHNOLOGY, 2014, 138 :55-64

← 1 2 3 4 5 →