2-PHENYL-6(7)-R-SUBSTITUTED QUINOXALINES N-OXIDES - SYNTHESIS, STRUCTURE ELUCIDATION AND ANTIMICROBIAL ACTIVITY

被引：23

作者：

LORIGA, M ^{[1
]}

NUVOLE, A ^{[1
]}

PAGLIETTI, G ^{[1
]}

FADDA, G ^{[1
]}

ZANETTI, S ^{[1
]}

机构：

[1] UNIV SASSARI,IST MICROBIOL & VIROL,I-07100 SASSARI,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 06期

关键词：

anti trichomonas vaginalis activity; NMR structure elucidation; quinoxaline-N-oxides;

D O I：

10.1016/0223-5234(90)90147-U

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A certain number of isomeric 2-phenylquinoxalines N-oxides bearing substituents at position 6 7 were prepared in order to investigate anti-microbial activity. The effect of some electron-withdrawing groups seem to increase an anti-Trichomonas vaginalis activity in vitro. Structure elucidation of 6-acetyl-2-phenylquinoxaline was achieved by an unambiguous synthesis. 1H NMR spectra of N-oxides were examined in detail to establish structure of parent quinoxalines. © 1990.

引用

页码：527 / 532

页数：6

共 9 条

[1]

BANNORE SN, 1975, INDIAN J CHEM, V13, P609

[2] THE ESTABLISHMENT OF VARIOUS TRICHOMONADS OF ANIMALS AND MAN IN AXENIC CULTURES [J].

DIAMOND, LS .

JOURNAL OF PARASITOLOGY, 1957, 43 (04) :488-490

[3]

Jones R., 1985, MANUAL CLIN MICROBIO, P972

[4] REACTION OF PHENACYLDIMETHYLSULFONIUM IODIDE WITH ORTHO-PHENYLENE-DIAMINES [J].

KANO, S ;

YUASA, Y .

HETEROCYCLES, 1981, 16 (09) :1449-1452

[5] SYNTHESIS OF QUINOXALINE DERIVATIVES THROUGH CONDENSATION OF 1,2-DIAMINOBENZENES WITH BETA-KETO SULFOXIDES [J].

KANO, S ;

SHIBUYA, S ;

YUASA, Y .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (07) :1559-1561

[6]

LORIGA M, 1986, J CHEM RES-S, P16

[7]

LORIGA M, 1989, J CHEM RES-S, P202

[8]

LORIGA M, 1989, J CHEM RES M, P1563

[9]

Loriga M., 1986, J CHEM RES M, P277

← 1 →