IN VITRO ANTICANCER ACTIVITY OF BIOPHYTUM SENSITIVUM WHOLE PLANT EXTRACTS AGAINST CERVICAL AND LIVER CANCER CELL LINES

被引：4
|
作者：
Shanthi, M. P. [1 ]
Bupesh, G. [2 ,3 ]
Magesh, S. [3 ]
Meenakurmari, K. [2 ]
Saravanan, K. [1 ]
Muthiah, N. S. [4 ]
机构：
[1] Nehru Mem Coll, Dept Zool, Puthanampatti, Tamil Nadu, India
[2] Bharath Univ, Cent Res Lab, Sree Balaji Med Coll & Hosp, Madras 600044, Tamil Nadu, India
[3] King Inst Prevent Med & Res, Dept Virol, Madras 600032, Tamil Nadu, India
[4] Bharath Univ, Dept Pharmacol, Sree Balaji Med Coll & Hosp, Madras 600044, Tamil Nadu, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2016年 / 7卷 / 12期
关键词：
Biophytum sensitivum; HELA; HEPG-2; Anticancer activity; MTT Assay;
D O I：
10.13040/IJPSR.0975-8232.7(12).5128-35
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study, the various extracts viz aqueous, ethanol, chloroform and Petroleum ether of Biophytum sensitivum whole plant were evaluated for the anticancer activity against cancer cell lines. The cervical (Hela) and liver cancer (HepG2) cell lines were used to screen the in vitro anticancer challenging with the B. sensitivum extracts. Concentration ranges from 20 to 100 microgram of B. s crude extracts were screened against Hela and HepG2 cells. The antiproliferative activity of B. sensitivum were performed by 3-[4,5-Dimethyl thiazol-2-yl]-2, 5-diphenyltetrazolium Bromide (MTT) assay. The cytotoxicity was highly significant in the ethanolic extract and chloroform extract than the aqueous and petroleum ether extract. The maximum non toxic concentration was observed at 150 mu g concentration of aqueous extract in the vero cell line.
引用
收藏
页码：5128 / 5135
页数：8
相关论文
共 50 条
  • [21] Cytotoxic Activity of Extracts from the Intact Plant and Cell Cultures of Podophyllum peltatum Against Cervical Cancer Cells
    M. P. Kitaeva
    A. A. Aksenov
    T. A. Fedotcheva
    A. V. Semeikin
    N. L. Shimanovsky
    Pharmaceutical Chemistry Journal, 2022, 56 : 361 - 365
  • [22] Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines
    Srivatchava, S.
    Roy, Anitha
    Kumar, S. Rajesh
    Raghunandhakumar, S.
    Thangavelu, Lakshmi
    JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH, 2021, 12 (04): : 48 - 54
  • [23] Antiurolithic and Antioxidant Activity of Ethanol Extract of Whole-plant Biophytum sensitivum (Linn.) DC in Ethylene-Glycol-induced Urolithiasis in Rats
    Abhirama, B. R.
    ShanmugaSundaram, R.
    PHARMACOGNOSY RESEARCH, 2018, 10 (02): : 181 - 187
  • [24] In vitro anticancer activity and induction of apoptosis by pterostilbene in human cancer cell lines
    Mazumder, UK
    Gupta, M
    Manikandan, L
    Bhattacharya, S
    Roy, M
    Chakraborty, S
    Senthilkumar, GP
    DRUG METABOLISM REVIEWS, 2003, 35 : 206 - 206
  • [25] Anticancer activity of Ashwagandha against human head and neck cancer cell lines
    Lee, Haeng-Eun
    Shin, Ji-Ae
    Jeong, Joseph H.
    Jeon, Jae-Gyu
    Lee, Min-Ho
    Cho, Sung-Dae
    JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2016, 45 (03) : 193 - 201
  • [26] Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines
    Sergazy, Shynggys
    Vetrova, Anastassiya
    Orhan, Ilkay Erdogan
    Deniz, Fatma Sezer Senol
    Kahraman, Ahmet
    Zhang, Jian-Ye
    Aljofan, Mohamad
    FUTURE SCIENCE OA, 2022, 8 (02):
  • [27] Anticancer Potentials of Zinc Oxide Nanoparticles against Liver and Breast Cancer Cell Lines
    Elsayed, E. A.
    Moussa, S. A.
    El-Enshasy, H. A.
    Wadaan, M. A.
    JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH, 2020, 79 (01): : 56 - 59
  • [28] In vitro anticancer activity of silver nanoparticle synthesized from Punica granatum dried peel against cancer cell lines
    Paarakh, M. Padmaa
    Jose, Preethy Ani
    INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES, 2020, 11 (04): : 224 - 238
  • [29] Activity of a Novel Hec1-Targeted Anticancer Compound against Breast Cancer Cell Lines In Vitro and In Vivo
    Huang, Lynn Y. L.
    Chang, Chia-Chi
    Lee, Ying-Shuan
    Chang, Jia-Ming
    Huang, Jiann-Jyh
    Chuang, Shih-Hsien
    Kao, Kuo-Jang
    Lau, Gillian M. G.
    Tsai, Pei-Yi
    Liu, Chia-Wei
    Lin, Her-Sheng
    Lau, Johnson Y. N.
    MOLECULAR CANCER THERAPEUTICS, 2014, 13 (06) : 1419 - 1430
  • [30] Anti Cancer Activity of Cassia Oleoresin Against Liver Cancer Cell Lines
    Harini, P.
    Roy, Anitha
    Raghunandhakumar, S.
    Elumalai, P.
    Lakshmi, T.
    JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH, 2021, 12 (04): : 24 - 29
12345