DIFFERENTIAL INDUCTION OF TRANSCRIPTION FOR GLUCOCORTICOID-RESPONSIVE GENES IN CULTURED RAT HEPATOCYTES

被引：12
作者：
NEBES, VL
DEFRANCO, D
MORRIS, SM
机构：
[1] UNIV PITTSBURGH,DEPT MICROBIOL BIOCHEM & MOLEC BIOL,PITTSBURGH,PA 15261
[2] UNIV PITTSBURGH,DEPT BIOL SCI,PITTSBURGH,PA 15261
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91921-E
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dexamethasone rapidly stimulated transcription of the tyrosine aminotransferase and metallothionein-I genes - but not the phosphoenolpyruvate carboxykinase gene - in rat hepatocytes cultured in serum-free medium. This differential response was not observed for cyclic AMP. The results suggest that the phosphoenolpyruvate carboxykinase gene - but not the tyrosine aminotransferase and metallothionein-I genes - requires a factor which is permissive for stimulation of transcription by the glucocorticoid receptor. © 1990.
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页码：133 / 138
页数：6
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