N-TERMINAL DOMAIN OF DYSTROPHIN

被引：20
|
作者：
BONETKERRACHE, A
FABBRIZIO, E
MORNET, D
机构：
[1] INSERM U 300, Faculté de Pharmacie, 34060 Montpellier, Avenue Charles Flahault
来源：
FEBS LETTERS | 1994年 / 355卷 / 01期
关键词：
DUCHENNE MUSCULAR DYSTROPHY; DYSTROPHIN; CALMODULIN; ACTIN; RECOMBINANT PROTEIN;
D O I：
10.1016/0014-5793(94)01162-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Contro-versial experiments have been published on calmodulin binding of dystrophin. In this study, we used recombinant proteins and the techniques of affinity chromatography and ELISA to show that the N-terminal part of dystrophin binds calmodulin specifically in a calcium-dependent manner. The calcium-dependent interaction of calmodulin and dystrophin does not directly regulate binding of actin to dystrophin, but may regulate dystrophin interactions with other associated proteins.
引用
收藏
页码：49 / 53
页数：5
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