BETA-AMINO KETONES AS KEY INTERMEDIATES IN THE SYNTHESIS OF PYRIDINES - A NOVEL AND EFFICIENT ROUTE TO ANNELATED BIPYRIDINES AND TERPYRIDINES

被引：25

作者：

WESTERWELLE, U ^{[1
]}

ESSER, A ^{[1
]}

RISCH, N ^{[1
]}

机构：

[1] UNIV BIELEFELD,FAK CHEM,POSTFACH 8640,W-4800 BIELEFELD,GERMANY

来源：

CHEMISCHE BERICHTE | 1991年 / 124卷 / 03期

关键词：

ANNELATED PYRIDINES; PREPARATION FROM MANNICH BASES; 5,6-DIHYDRO-1,10-PHENANTHROLINES, SUBSTITUTED; 4,5-DIAZAFLUORENES, SUBSTITUTED;

D O I：

10.1002/cber.19911240324

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hydrochlorides of beta-amino ketones 1a-e (Mannich bases) are easily obtained starting compounds for a novel synthesis of pyridines. Condensation with the heteroaromatic ketones 8, 9, and 10 yields 5,6-dihydro-1,10-phenanthrolines 3a-d, 13 and 4,5-diazafluorenes 4a-d, which have not yet been described in literature. Symmetrical terpyridines 3e, 4e are formed in a one-step reaction of 8, 9 with dimethylmethylen-ammonium chloride in the presence of an ammonia source.

引用

页码：571 / 576

页数：6

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