CYTOTOXIC EFFECTS OF FOOD-ADDITIVES AND PHARMACEUTICALS ON CELLS IN CULTURE AS DETERMINED WITH THE NEUTRAL RED ASSAY

被引：39
作者：
BABICH, H [1 ]
BORENFREUND, E [1 ]
机构：
[1] ROCKEFELLER UNIV, LAB ANIM RES CTR, NEW YORK, NY 10021 USA
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1990年 / 79卷 / 07期
关键词：
D O I：
10.1002/jps.2600790709
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The acute cytotoxicity of butylated hydroxytoluene and butylated hydroxyanisole to cultured human dermal fibroblasts, keratinocytes, melanocytes, and melanoma tumor cells was determined with the neutral red assay. For all cell types, butylated hydroxytoluene proved to be more cytotoxic than butylated hydroxyanisole. The neutral red assay is a rapid, economical, semiautomated assay that can be used with a variety of cell types in culture to provide quantitated data that can be used to rank test agents according to their potencies. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：592 / 594
页数：3
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