NUCLEOLAR ORGANIZER REGIONS ARE INDEPENDENTLY ASSOCIATED WITH A SHORTENED SURVIVAL IN PATIENTS WITH NONSMALL CELL LUNG-CANCER

被引：6
作者：
OYAMA, T
MITSUDOMI, T
YOSHIDA, Y
MIZOUE, T
HAMADA, T
SHIRAKUSA, T
机构：
[1] Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu
[2] Department of Clinical Epidemiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu
[3] Department of Pathology II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu
来源：
SURGICAL ONCOLOGY-OXFORD | 1993年 / 2卷 / 06期
关键词：
AG-NOR; MULTIVARIATE ANALYSIS; NONSMALL CELL LUNG CANCER; SURVIVAL;
D O I：
10.1016/0960-7404(93)90065-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We examined nucleolar organizer regions (Ag-NOR) in 102 patients with non-small cell lung cancer (NSCLC). Ag-NOR counts were generally higher in tumours from more advanced stages, or in poorly differentiated adenocarcinomas. Six potential prognostic indicators included sex, age, year of operation, histology, stage and Ag-NOR count. Stage and Ag-NOR counts had a significant prognostic value in the univariate analysis for 79 patients who died of their lung cancer. In the multivariate analysis, high Ag-NOR counts as well as disease stage were independently associated with a poor prognosis. Furthermore we divided patients into three groups according to their Ag-NOR counts and found that in patients with stage I and II disease higher Ag-NOR counts were associated with shortened survival. This trend did not continue in patients with stage III and IV disease.
引用
收藏
页码：341 / 347
页数：7
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