MEASUREMENT OF NERVE GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN HUMAN BRAIN USING AN ANTI-MOUSE-NGF ENZYME-IMMUNOASSAY

被引：8

作者：

BERTRAND, P

ROGER, O

HOULGATTE, R

JAVOYAGID, F

BRANDEL, JP

DOBLE, A

BLANCHARD, JC

机构：

[1] CTR HOSP REG & UNIV,INSERM,U298,F-49033 ANGERS,FRANCE

[2] HOP LA PITIE SALPETRIERE,INSERM,U289,F-75651 PARIS 13,FRANCE

来源：

NEUROCHEMISTRY INTERNATIONAL | 1992年 / 20卷 / 02期

关键词：

D O I：

10.1016/0197-0186(92)90170-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nerve growth factor (NGF) like immunoreactivity, expressed as mouse 2.5S nerve growth factor equivalents, was evaluated in three structures of the human brain post-mortem using a commercially available enzyme immunoassay. Regional differences in NGF-like immunoreactivity were observed. Highest levels were found in hippocampus (148 pg/g) compared to putamen (76 pg/g) and frontal cortex (34 pg/g). In addition, these results suggest differences in the distribution of brain NGF between human and rodent, where relatively high levels of NGF are found in the cortex.

引用

收藏

页码：215 / 218

页数：4

相关论文

共 18 条

[1] A UNIFYING HYPOTHESIS FOR THE CAUSE OF AMYOTROPHIC LATERAL SCLEROSIS, PARKINSONISM, AND ALZHEIMER-DISEASE [J].

APPEL, SH .

ANNALS OF NEUROLOGY, 1981, 10 (06) :499-505

[2] NEURONAL LOSS, NEUROFIBRILLARY TANGLES AND GRANULOVACUOLAR DEGENERATION IN HIPPOCAMPUS WITH AGING AND DEMENTIA - QUANTITATIVE STUDY [J].

BALL, MJ .

ACTA NEUROPATHOLOGICA, 1977, 37 (02) :111-118

[3] ALZHEIMERS-DISEASE - A DISORDER OF CORTICAL CHOLINERGIC INNERVATION [J].

COYLE, JT ;

PRICE, DL ;

DELONG, MR .

SCIENCE, 1983, 219 (4589) :1184-1190

[4] EFFECTS OF NERVE GROWTH-FACTOR ON CHOLINERGIC BRAIN NEURONS [J].

DREYFUS, CF .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (04) :145-149

[5] NERVE GROWTH-FACTOR MESSENGER-RNA IN PERIPHERAL AND CENTRAL RAT-TISSUES AND IN THE HUMAN CENTRAL-NERVOUS-SYSTEM - LESION EFFECTS IN THE RAT-BRAIN AND LEVELS IN ALZHEIMERS-DISEASE [J].

GOEDERT, M ;

FINE, A ;

HUNT, SP ;

ULLRICH, A .

MOLECULAR BRAIN RESEARCH, 1986, 1 (01) :85-92

[6] NERVE GROWTH-FACTOR AND ALZHEIMERS-DISEASE [J].

HEFTI, F ;

WEINER, WJ .

ANNALS OF NEUROLOGY, 1986, 20 (03) :275-281

[7] IS ALZHEIMER-DISEASE CAUSED BY LACK OF NERVE GROWTH-FACTOR [J].

HEFTI, F .

ANNALS OF NEUROLOGY, 1983, 13 (01) :109-110

[8]

HEFTI F, 1989, NEUROBIOL AGING, V10, P515, DOI 10.1016/0197-4580(89)90118-8

[9] NERVE GROWTH-FACTOR (NGF) IS PRESENT IN HUMAN-PLACENTA AND SEMEN, BUT UNDETECTABLE IN NORMAL AND PAGETS-DISEASE BLOOD - MEASUREMENTS WITH AN ANTI-MOUSE-NGF ENZYME-IMMUNOASSAY USING A RECOMBINANT HUMAN NGF REFERENCE [J].

HEINRICH, G ;

MEYER, TE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 155 (01) :482-486

[10] NERVE GROWTH-FACTOR LEVELS AND CHOLINE-ACETYLTRANSFERASE ACTIVITY IN THE BRAIN OF AGED RATS WITH SPATIAL MEMORY IMPAIRMENTS [J].

HELLWEG, R ;

FISCHER, W ;

HOCK, C ;

GAGE, FH ;

BJORKLUND, A ;

THOENEN, H .

BRAIN RESEARCH, 1990, 537 (1-2) :123-130