A Green Recyclable Poly(4-vinylpyridine)-Supported Copper Iodide Nanoparticles Catalyst for the Multicomponent Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones

Dihydropyrimidone derivatives are important class of compounds that received significant attention from many pharmaceutical and organic chemists because of the broad spectrum of their biological and pharmaceutical properties such as antibacterial, anti-inflammatory, and antivirial properties. Aromatic aldehydes containing both electron-donating and electron-withdrawing groups were also reacted under the same reaction conditions to produce the corresponding DHPMs in good to high yields. Methyl acetoacetate and thiourea were also used with similar success to provide the corresponding products. Aliphatic aldehydes remain intact under the same reaction conditions. The solid products were easily recrystallized from hot ethanol and were obtained in good to high yields during short reaction times. Very low amount of the catalyst is needed. Moreover, our procedure is environmentally friendly as it does not use any toxic auxiliary or solvent. A distinct characterization of the present method, illustrated in this work is the formation of corresponding products without by-product.