Interpretation of a complex STR DNA profile using EuroForMix

被引：4

作者：

Bleka, Oyvind ^{[1
,2
]}

Gill, Peter ^{[1
,2
]}

机构：

[1] Norwegian Inst Publ Hlth, Dept Forens Biol, Sognsvannsveien 20, N-0372 Oslo, Norway

[2] Univ Oslo, Oslo, Norway

来源：

FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES | 2015年 / 5卷

关键词：

STR mixtures; Statistical modeling; Strength of evidence;

D O I：

10.1016/j.fsigss.2015.09.160

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The freely available open source software named EuroForMix implements a statistical model to explain the variation of the allelic peak height from the PCR-process. The model considers mixture proportion, peak height distribution properties, stutter proportion and degradation slope as unknown parameters. EuroForMix supports two inference approaches. The first uses maximum likelihood estimation of the unknown parameters. The second is Bayesian based and integrates out the unknown parameters by specified prior distributions. In this article we consider both approaches to evaluate a complex real case example. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E405 / E406

页数：2