BRAIN NITRIC-OXIDE SYNTHASE IS A HEMOPROTEIN

被引：140

作者：

KLATT, P ^{[1
]}

SCHMIDT, K ^{[1
]}

MAYER, B ^{[1
]}

机构：

[1] GRAZ UNIV,INST PHARMACOL & TOXIKOL,UNIV PL 2,A-8010 GRAZ,AUSTRIA

来源：

BIOCHEMICAL JOURNAL | 1992年 / 288卷

关键词：

D O I：

10.1042/bj2880015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain nitric oxide (NO) synthase showed pyridine haemochrome spectra typical of ferroprotoporphyrin IX-containing enzymes. The haem content of purified NO synthase was in the range 0.7-0.9 mol/mol of 160 kDa subunit. In the presence of CO, NO, KCN and miconazole, the L-citrulline-forming activity of NO synthase was markedly diminished, demonstrating that enzyme-bound haem is involved in enzymic NO synthesis.

引用

页码：15 / 17

页数：3

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