REGIONAL SUBLOCALIZATION OF THE HUMAN CD69 GENE TO CHROMOSOME BANDS 12P12.3-P13.2, THE PREDICTED REGION OF THE HUMAN NATURAL-KILLER-CELL GENE-COMPLEX

被引：24
作者：
SCHNITTGER, S
HAMANN, J
DANNENBERG, C
FIEBIG, H
STRAUSS, M
FONATSCH, C
机构：
[1] MED UNIV LUBECK,INST HUMANGENET ARBEITSGRP TUMORCYTOGENET,LUBECK,GERMANY
[2] UNIV LEIPZIG,WB ZOOL 2,FACHBEREICH BIOWISSENSCH,O-7010 LEIPZIG,GERMANY
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1993年 / 23卷 / 10期
关键词：
CD69 NATURAL KILLER CELL GENE COMPLEX; CHROMOSOMAL SUBLOCALIZATION; FLUORESCENCE IN-SITU HYBRIDIZATION;
D O I：
10.1002/eji.1830231051
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal region in mouse, termed the NK gene complex. The human homologue of this complex is likely to reside on chromosome 12 near the PRP locus (12p13.2). By analyzing T cell hybrids, the CD69 gene was previously mapped to human chromosome 12. Here we report the regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, suggesting that CD69 belongs to one linkage group together with different cell surface molecules on NK cells.
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收藏
页码：2711 / 2713
页数：3
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