Diabetic Retinopathy and VEGF

被引：374

作者：

Gupta, N. ^{[1
]}

Mansoor, S. ^{[1
,2
]}

Sharma, A. ^{[1
,3
]}

Sapkal, A. ^{[1
]}

Sheth, J. ^{[3
]}

Falatoonzadeh, P. ^{[1
]}

Kuppermann, B. D. ^{[1
]}

Kenney, M. C. ^{[1
]}

机构：

[1] Univ Calif Irvine, Gavin Herbert Eye Inst, 843 Hlth Sci Rd,Hewitt Hall,Room 2028, Irvine, CA 92679 USA

[2] Georgia Inst Technol, Dept Chem & Biomol Engn, Atlanta, GA 30333 USA

[3] Lotus Eye Care Hosp, Dept Ophthalmol, Coimbatore, TN, India

来源：

OPEN OPHTHALMOLOGY JOURNAL | 2013年 / 7卷

关键词：

Diabetic retinopathy; VEGF; DME; diabetes; central retinal vein occlusion; PGF;

D O I：

10.2174/1874364101307010004

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Diabetic retinopathy remains the leading vascular-associated cause of blindness throughout the world. Its treatment requires a multidisciplinary interventional approach at both systemic and local levels. Current management includes laser photocoagulation, intravitreal steroids, and anti-vascular endothelial growth factor (VEGF) treatment along with systemic blood sugar control. Anti-VEGF therapies, which are less destructive and safer than laser treatments, are being explored as primary therapy for the management of vision-threatening complications of diabetic retinopathy such as diabetic macular edema (DME). This review provides comprehensive information related to VEGF and describes its role in the pathogenesis of diabetic retinopathy, and in addition, examines the mechanisms of action for different antiangiogenic agents in relation to the management of this disease. Medline (Pubmed) searches were carried out with keywords "VEGF", "diabetic retinopathy", and "diabetes" without any year limitation to review relevant manuscripts used for this article.

引用

页码：4 / 10

页数：7

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