SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 6 NEW ANALOGS OF ARGININE-VASOPRESSIN SUBSTITUTED IN POSITION 2 WITH BETA-THIENYLALANINE OR PROLONGED ON THE N-TERMINUS WITH 1-ADAMANTANEACETIC ACID

被引：1

作者：

KONIECZNA, E ^{[1
]}

CZAJA, M ^{[1
]}

LAMMEK, B ^{[1
]}

SLANINOVA, J ^{[1
]}

机构：

[1] CZECHOSLOVAK ACAD SCI, INST ORGAN CHEM & BIOCHEM, CS-16610 PRAGUE 6, CZECHOSLOVAKIA

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1993年 / 58卷 / 12期

关键词：

D O I：

10.1135/cccc19932994

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six new analogs of arginine-vasopressin, four of them substituted in position 2 with beta-thienylalanine, and two prolonged on the N-terminus by acylation with I-adamantaneacetic acid, were synthesized on chlormethylated resin using Boc strategy and DCC or DCC-HOBt to form peptide bond. The activity of the analogs was fairly low, however, one of the peptides, namely [Cpp1, Thi2, Val4]AVP, showed selectivity in antiuterotonic, antipressor and anti-antidiuretic effects.

引用

页码：2994 / 2999

页数：6

共 2 条

[1] SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 3 NEW ANALOGS OF ARGININE-VASOPRESSIN MODIFIED IN POSITIONS 1,2,4 AND 9
LAMMEK, B
DERDOWSKA, I
MELIN, P
POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, 1989, 41 (01): : 97 - 102
[2] SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF NEW 1,2,3-SUBSTITUTED 1,2,3,4-TETRAHYDRO-BETA-CARBOLINES
POGOSYAN, SA
MATEVOSYAN, LA
MELIKOGANJANNYAN, AS
SAFRAZBEKYAN, RR
ARZANUNTS, EM
SARKISYAN, IS
PARONIKYAN, RG
AKOPYAN, NE
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1986, 20 (10): : 1191 - 1195

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