SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NOVEL 2-THIO DERIVATIVES OF ATP

被引：28

作者：

ZIMMET, J

JARLEBARK, L

HAMMARBERG, T

VANGALEN, PJM

JACOBSON, KA

HEILBRONN, E

机构：

[1] UNIV STOCKHOLM,NEUROCHEM & NEUROTOXICOL UNIT,S-10691 STOCKHOLM,SWEDEN

[2] NIDDKD,BIOORGAN CHEM LAB,BETHESDA,MD 20892

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 01期

关键词：

D O I：

10.1080/07328319308016190

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Alkylthio analogues of adenosine 5'-triphosphate were synthesized and evaluated as P2y purinocepter agonists. ATP and analogues transiently increased intracellular Ca2+ levels in C6 glioma cells and in skeletal muscle derived myotubes in culture. Most derivatives were resistant to stepwise dephosphorylation by ecto-ATPases.

引用

页码：1 / 20

页数：20

共 50 条

[1] SYNTHESIS, CHEMISTRY AND BIOLOGICAL-ACTIVITY OF NOVEL THIENOPYRAN DERIVATIVES
MCNALLY, JJ
PRESS, JB
SANFILIPPO, PJ
URBANSKI, MJ
KATZ, LB
FALOTICO, R
GIARDINO, E
MOORE, JB
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 153 - ORGN
[2] Design, Synthesis and Biological Evaluation of 2-Thio Benzoxazole Derivatives as Anti-Inflammatory and Analgesic Agents
Yin, Di
Gao, Xiang
Li, Qing
Zhao, Nong
Long, Sheng-jing
LATIN AMERICAN JOURNAL OF PHARMACY, 2016, 35 (08): : 1701 - 1709
[3] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-MERCAPTOIMIDAZOLE DERIVATIVES
POVSTYANOY, MV
PRIYMENKO, BA
KOCHERGIN, PM
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1978, 12 (05): : 59 - 62
[4] SYNTHESIS OF 2-THIO ANALOGS OF THIAMINE
OKUDA, T
PRICE, CC
JOURNAL OF ORGANIC CHEMISTRY, 1959, 24 (01): : 14 - 16
[5] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ADAMANTANE DERIVATIVES
FRIDMAN, AL
SIVKOVA, MP
ZALESOV, VS
DOLBILKIN, KV
MOISEEV, IK
DOROSHENKO, RI
MANZHELEVSKAYA, EV
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1979, 13 (12): : 24 - 31
[6] SYNTHESIS OF DIFURAN DERIVATIVES AND THEIR BIOLOGICAL-ACTIVITY
HISHMAT, OH
ELEBRASHI, NMA
SHALASH, MR
ISMAIL, I
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1979, 29-2 (08): : 1081 - 1083
[7] DERIVATIVES OF INDOLINDOLES - SYNTHESIS AND BIOLOGICAL-ACTIVITY
SAMSONIYA, SA
ESAKIYA, NA
DOLIDZE, SV
TRAPAIDZE, MV
LOMTATIDZE, ZS
SUVOROV, NN
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1991, 25 (09): : 40 - 43
[8] SYNTHESIS AND EVALUATION OF BIOLOGICAL-ACTIVITY OF 2 NOVEL TRITIUM-LABELED DERIVATIVES OF RIODIPINE
SHEVCHENKO, VP
MYASOEDOV, NF
SOLDATOV, NM
DUBURS, GJ
KASTRON, VV
SKRASTINS, IP
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1989, 27 (06): : 721 - 730
[9] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4'-THIO ANALOGS OF ANTIBIOTIC TOYOCAMYCIN
BOBEK, M
BLOCH, A
WHISTLER, RL
JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (02) : 168 - &
[10] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NOVEL THYMIDINE DERIVATIVES OF PODOPHYLLOTOXIN AND 4'-DEMETHYLEPIPODOPHYLLOTOXIN
DERRY, WB
PAMIDI, CC
GUPTA, RS
ANTI-CANCER DRUG DESIGN, 1993, 8 (03): : 203 - 221

← 1 2 3 4 5 →