THE GENE FOR TISSUE INHIBITOR OF METALLOPROTEINASES-2 IS LOCALIZED ON HUMAN-CHROMOSOME ARM-17Q25

被引：33
作者：
DECLERCK, Y
SZPIRER, C
ALY, MS
CASSIMAN, JJ
EECKHOUT, Y
ROUSSEAU, G
机构：
[1] UNIV SO CALIF,LOS ANGELES,CA 90089
[2] UNIV LIBRE BRUXELLES,DEPT MOLEC BIOL,B-1640 RHODE ST GENESE,BELGIUM
[3] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,B-3000 LOUVAIN,BELGIUM
[4] CATHOLIC UNIV LOUVAIN,INT INST CELLULAR & MOLEC PATHOL,B-1200 BRUSSELS,BELGIUM
来源：
GENOMICS | 1992年 / 14卷 / 03期
关键词：
D O I：
10.1016/S0888-7543(05)80186-7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Tissue inhibitor of metalloproteinases-2 (TIMP2) is a natural inhibitor of several proteinases that are involved in the degradation of the extracellular matrix. By means of somatic cell hybrids segregating human chromosomes, the gene encoding this inhibitor was assigned to human chromosome 17. Fluorescence in situ hybridization confirmed this assignment and allowed mapping of the gene to the terminal region (17q25) of the chromosome. © 1992 Academic Press, Inc. All rights reserved.
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页码：782 / 784
页数：3
相关论文
共 10 条
[1]   CDNA CLONING AND EXPRESSION OF A METALLOPROTEINASE INHIBITOR RELATED TO TISSUE INHIBITOR OF METALLOPROTEINASES [J].
BOONE, TC ;
JOHNSON, MJ ;
DECLERCK, YA ;
LANGLEY, KE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2800-2804
[2]   PURIFICATION OF RABBIT BONE INHIBITOR OF COLLAGENASE [J].
CAWSTON, TE ;
GALLOWAY, WA ;
MERCER, E ;
MURPHY, G ;
REYNOLDS, JJ .
BIOCHEMICAL JOURNAL, 1981, 195 (01) :159-165
[3]  
DECLERCK YA, 1989, J BIOL CHEM, V264, P17445
[4]   METALLOPROTEINASES AND THEIR INHIBITORS IN MATRIX REMODELING [J].
MATRISIAN, LM .
TRENDS IN GENETICS, 1990, 6 (04) :121-125
[5]   REPORT OF THE COMMITTEE-ON-THE-GENETIC-CONSTITUTION-OF-CHROMOSOME-17 [J].
SOLOMON, E ;
LEDBETTER, DH .
CYTOGENETICS AND CELL GENETICS, 1991, 58 (1-2) :686-738
[6]   DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS [J].
SOUTHERN, EM .
JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (03) :503-+
[7]  
STETLERSTEVENSON WG, 1989, J BIOL CHEM, V264, P17374
[8]   THE SP1 TRANSCRIPTION FACTOR GENE (SP1) AND THE 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR GENE (VDR) ARE COLOCALIZED ON HUMAN-CHROMOSOME ARM 12Q AND RAT CHROMOSOME-7 [J].
SZPIRER, J ;
SZPIRER, C ;
RIVIERE, M ;
LEVAN, G ;
MARYNEN, P ;
CASSIMAN, JJ ;
WIESE, R ;
DELUCA, HF .
GENOMICS, 1991, 11 (01) :168-173
[9]  
WILLARD HF, 1989, HUM GENET, V81, P234
[10]  
ZHANG ZH, 1991, BLOOD, V78, P2396
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