The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors

被引：28

作者：

Lin, Luping ^{[1
,2
]}

Bivona, Trever G. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Div Hematol & Med Oncol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期

关键词：

BRAF; Hippo; MEK; resistance; RAS; targeted therapy; YAP;

D O I：

10.1080/23723556.2015.1021441

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RAF- and MEK-targeted therapies are approved for patients with BRAFV600E melanoma and under investigation in a several other tumor types, but resistance remains a major challenge. We uncovered yes-associated protein 1 (YAP1) as a mechanism of resistance to RAF-MEK inhibition in BRAF- and RAS-mutant cancers, providing a rationale for co-targeting YAP and RAF-MEK to enhance patient outcomes.

引用

页数：2

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