The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors

被引：27

作者：

Lin, Luping ^{[1
,2
]}

Bivona, Trever G. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Div Hematol & Med Oncol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期

关键词：

BRAF; Hippo; MEK; resistance; RAS; targeted therapy; YAP;

D O I：

10.1080/23723556.2015.1021441

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RAF- and MEK-targeted therapies are approved for patients with BRAFV600E melanoma and under investigation in a several other tumor types, but resistance remains a major challenge. We uncovered yes-associated protein 1 (YAP1) as a mechanism of resistance to RAF-MEK inhibition in BRAF- and RAS-mutant cancers, providing a rationale for co-targeting YAP and RAF-MEK to enhance patient outcomes.

引用

页数：2

共 9 条

[1] Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
Bollag, Gideon
Hirth, Peter
Tsai, James
Zhang, Jiazhong
Ibrahim, Prabha N.
Cho, Hanna
Spevak, Wayne
Zhang, Chao
Zhang, Ying
Habets, Gaston
Burton, ElizabethA.
Wong, Bernice
Tsang, Garson
West, Brian L.
Powell, Ben
Shellooe, Rafe
Marimuthu, Adhirai
Nguyen, Hoa
Zhang, Kam Y. J.
Artis, Dean R.
Schlessinger, Joseph
Su, Fei
Higgins, Brian
Iyer, Raman
D'Andrea, Kurt
Koehler, Astrid
Stumm, Michael
Lin, Paul S.
Lee, Richard J.
Grippo, Joseph
Puzanov, Igor
Kim, Kevin B.
Ribas, Antoni
McArthur, Grant A.
Sosman, Jeffrey A.
Chapman, Paul B.
Flaherty, Keith T.
Xu, Xiaowei
Nathanson, Katherine L.
Nolop, Keith
[J]. NATURE, 2010, 467 (7315) : 596 - 599
[2] Circumventing Cancer Drug Resistance in the Era of Personalized Medicine
Garraway, Levi A.
Jaenne, Pasi A.
[J]. CANCER DISCOVERY, 2012, 2 (03) : 214 - 226
[3] The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
Lin, Luping
Sabnis, Amit J.
Chan, Elton
Olivas, Victor
Cade, Lindsay
Pazarentzos, Evangelos
Asthana, Saurabh
Neel, Dana
Yan, Jenny Jiacheng
Lu, Xinyuan
Pham, Luu
Wang, Mingxue M.
Karachaliou, Niki
Gonzalez Cao, Maria
Luis Manzano, Jose
Luis Ramirez, Jose
Sanchez Torres, Jose Miguel
Buttitta, Fiamma
Rudin, Charles M.
Collisson, Eric A.
Algazi, Alain
Robinson, Eric
Osman, Iman
Munoz-Couselo, Eva
Cortes, Javier
Frederick, Dennie T.
Cooper, Zachary A.
McMahon, Martin
Marchetti, Antonio
Rosell, Rafael
Flaherty, Keith T.
Wargo, Jennifer A.
Bivona, Trever G.
[J]. NATURE GENETICS, 2015, 47 (03) : 250 - +
[4] Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer
Lin, Luping
Asthana, Saurabh
Chan, Elton
Bandyopadhyay, Sourav
Martins, Maria M.
Olivas, Victor
Yan, Jenny Jiacheng
Pham, Luu
Wang, Mingxue Michelle
Bollag, Gideon
Solit, David B.
Collisson, Eric A.
Rudin, Charles M.
Taylor, Barry S.
Bivona, Trever G.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (07) : E748 - E757
[5] The emerging roles of YAP and TAZ in cancer
Moroishi, Toshiro
Hansen, Carsten Gram
Guan, Kun-Liang
[J]. NATURE REVIEWS CANCER, 2015, 15 (02) : 73 - 79
[6] Genetics and biomarkers in personalisation of lung cancer treatment
Rosell, Rafael
Bivona, Trever G.
Karachaliou, Niki
[J]. LANCET, 2013, 382 (9893) : 720 - 731
[7] Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: A Policy Statement from the American Association for Cancer Research
Sawyers, Charles L.
van't Veer, Laura J.
[J]. CLINICAL CANCER RESEARCH, 2014, 20 (19) : 4978 - 4981
[8] The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
Varelas, Xaralabos
[J]. DEVELOPMENT, 2014, 141 (08): : 1614 - 1626
[9] Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction
Zhang, Zhisen
Lin, Zhaohu
Zhou, Zheng
Shen, Hong C.
Yan, S. Frank
Mayweg, Alexander V.
Xu, Zhiheng
Qin, Ning
Wong, Jason C.
Zhang, Zhenshan
Rong, Yiping
Fry, David C.
Hu, Taishan
[J]. ACS MEDICINAL CHEMISTRY LETTERS, 2014, 5 (09): : 993 - 998

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