THE WNT FAMILY OF DEVELOPMENTAL REGULATORS

被引：135
作者：
MCMAHON, AP
机构：
来源：
TRENDS IN GENETICS | 1992年 / 8卷 / 07期
关键词：
D O I：
10.1016/0168-9525(92)90122-K
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Since its initial identification in mouse mammary tumors, the proto-oncogene Wnt-1 has been shown to encode a member of a family of putative signalling molecules. Recent work has implicated Wnt-1, and other members of the Wnt gene family, in regulation of a number of basic developmental processes in Drosophila, Xenopus and the mouse. These studies are leading to a new appreciation of the normal and oncogenic actions of Wnt genes.
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页码：236 / 242
页数：7
相关论文
共 59 条
[1]   PLURIPOTENTIALITY OF THE 2-DAY-OLD AVIAN GERMINATIVE NEUROEPITHELIUM [J].
ALVARADOMALLART, RM ;
MARTINEZ, S ;
LANCEJONES, CC .
DEVELOPMENTAL BIOLOGY, 1990, 139 (01) :75-88
[2]   EXPRESSION OF A DOMINANT NEGATIVE MUTANT OF THE FGF RECEPTOR DISRUPTS MESODERM FORMATION IN XENOPUS EMBRYOS [J].
AMAYA, E ;
MUSCI, TJ ;
KIRSCHNER, MW .
CELL, 1991, 66 (02) :257-270
[3]  
ARIAS AM, 1988, DEVELOPMENT, V103, P157
[4]   EMBRYONIC AND IMAGINAL REQUIREMENTS FOR WINGLESS, A SEGMENT-POLARITY GENE IN DROSOPHILA [J].
BAKER, NE .
DEVELOPMENTAL BIOLOGY, 1988, 125 (01) :96-108
[5]   MOLECULAR-CLONING OF SEQUENCES FROM WINGLESS, A SEGMENT POLARITY GENE IN DROSOPHILA - THE SPATIAL-DISTRIBUTION OF A TRANSCRIPT IN EMBRYOS [J].
BAKER, NE .
EMBO JOURNAL, 1987, 6 (06) :1765-1773
[6]  
BEJSOVEC A, 1991, DEVELOPMENT, V113, P471
[7]  
BLASBAND A, 1992, ONCOGENE, V7, P153
[8]   THE PROTOONCOGENE INT-1 ENCODES A SECRETED PROTEIN ASSOCIATED WITH THE EXTRACELLULAR-MATRIX [J].
BRADLEY, RS ;
BROWN, AMC .
EMBO JOURNAL, 1990, 9 (05) :1569-1575
[9]   IDENTIFICATION OF PROTEIN PRODUCTS ENCODED BY THE PROTOONCOGENE INT-1 [J].
BROWN, AMC ;
PAPKOFF, J ;
FUNG, YKT ;
SHACKLEFORD, GM ;
VARMUS, HE .
MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (11) :3971-3977
[10]   A RETROVIRUS VECTOR EXPRESSING THE PUTATIVE MAMMARY ONCOGENE INT-1 CAUSES PARTIAL TRANSFORMATION OF A MAMMARY EPITHELIAL-CELL LINE [J].
BROWN, AMC ;
WILDIN, RS ;
PRENDERGAST, TJ ;
VARMUS, HE .
CELL, 1986, 46 (07) :1001-1009
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