A PROSPECTIVE, RANDOMIZED DOUBLE-BLIND CROSSOVER STUDY TO EXAMINE THE EFFICACY OF SR-89 IN PAIN PALLIATION IN PATIENTS WITH ADVANCED PROSTATE-CANCER METASTATIC TO BONE

被引：222

作者：

LEWINGTON, VJ

MCEWAN, AJ

ACKERY, DM

BAYLY, RJ

KEELING, DH

MACLEOD, PM

PORTER, AT

ZIVANOVIC, MA

机构：

[1] CROSS CANC INST,DEPT NUCL MED,EDMONTON T6G 1Z2,ALBERTA,CANADA

[2] AMERSHAM INT PLC,AMERSHAM,ENGLAND

[3] DERRIFORD HOSP,DEPT NUCL MED,PLYMOUTH,ENGLAND

[4] CROSS CANC INST,DEPT RADIAT ONCOL,EDMONTON T6G 1Z2,ALBERTA,CANADA

[5] FREEDOM FIELDS HOSP,DEPT RADIOTHERAPY,PLYMOUTH,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 08期

关键词：

D O I：

10.1016/0277-5379(91)90257-E

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The palliative efficacy of strontium-89 chloride has been evaluated in a prospective double-blind crossover study comparing it with stable strontium as placebo in 32 patients with prostate cancer metastatic to bone. Response was assessed 5 weeks after each treatment. 26 patients were evaluable. Complete pain relief was only reported following strontium-89 injection. Statistical comparison between placebo and strontium-89 showed clear evidence of a therapeutic response to strontium-89 compared with only a limited placebo effect (P < 0.01).

引用

页码：954 / 958

页数：5

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