A PROSPECTIVE, RANDOMIZED DOUBLE-BLIND CROSSOVER STUDY TO EXAMINE THE EFFICACY OF SR-89 IN PAIN PALLIATION IN PATIENTS WITH ADVANCED PROSTATE-CANCER METASTATIC TO BONE

被引：221
作者：
LEWINGTON, VJ
MCEWAN, AJ
ACKERY, DM
BAYLY, RJ
KEELING, DH
MACLEOD, PM
PORTER, AT
ZIVANOVIC, MA
机构：
[1] CROSS CANC INST,DEPT NUCL MED,EDMONTON T6G 1Z2,ALBERTA,CANADA
[2] AMERSHAM INT PLC,AMERSHAM,ENGLAND
[3] DERRIFORD HOSP,DEPT NUCL MED,PLYMOUTH,ENGLAND
[4] CROSS CANC INST,DEPT RADIAT ONCOL,EDMONTON T6G 1Z2,ALBERTA,CANADA
[5] FREEDOM FIELDS HOSP,DEPT RADIOTHERAPY,PLYMOUTH,ENGLAND
来源：
EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 08期
关键词：
D O I：
10.1016/0277-5379(91)90257-E
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The palliative efficacy of strontium-89 chloride has been evaluated in a prospective double-blind crossover study comparing it with stable strontium as placebo in 32 patients with prostate cancer metastatic to bone. Response was assessed 5 weeks after each treatment. 26 patients were evaluable. Complete pain relief was only reported following strontium-89 injection. Statistical comparison between placebo and strontium-89 showed clear evidence of a therapeutic response to strontium-89 compared with only a limited placebo effect (P < 0.01).
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页码：954 / 958
页数：5
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