EVIDENCE FOR AN INTRACEREBRAL ACTION OF PHENYLALANINE IN STIMULATION OF PROLACTIN SECRETION - INTERACTION OF LARGE NEUTRAL AMINO-ACIDS

被引：11

作者：

CARLSON, HE

HYMAN, DB

BLITZER, MG

机构：

[1] VET ADM MED CTR, RES SERV, NORTHPORT, NY 11768 USA

[2] SUNY STONY BROOK, DEPT MED, STONY BROOK, NY 11794 USA

[3] TULANE UNIV, MED CTR, HUMAN GENET PROGRAM, NEW ORLEANS, LA 70112 USA

[4] UNIV MARYLAND, SCH MED, DEPT PEDIAT, BALTIMORE, MD 21201 USA

[5] UNIV MARYLAND, SCH MED, DEPT OBSTET & GYNECOL, BALTIMORE, MD 21201 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1990年 / 70卷 / 03期

关键词：

D O I：

10.1210/jcem-70-3-814

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phenylalanine stimulates PRL secretion when given orally or iv to normal individuals. To differentiate between hypothalamic and pituitary sites of action, we examined the effects of concurrent infusion of valine on the PRL response to iv phenylalanine in eight normal men. Since large neutral amino acids share the same high affinity blood-brain barrier transport system, entry of phenylalanine into the brain will be diminished by the simultaneous presence of high serum concentrations of valine; the pituitary, lying outside the blood-brain barrier, is not subject to these competitive effects. Valine significantly blunted the PRL response to phenylalanine, supporting an effect of phenylalanine within the blood-brain barrier to stimulate PRL release. © 1990 by The Endocrine Society.

引用

页码：814 / 816

页数：3

共 10 条

[1] FREE TYROSINE LEVELS OF RAT-BRAIN AND TISSUES WITH SYMPATHETIC INNERVATION FOLLOWING ADMINISTRATION OF L-TYROSINE IN THE PRESENCE AND ABSENCE OF LARGE NEUTRAL AMINO-ACIDS [J].