ROLE OF HYPERTONICITY IN THE ENDOTHELIAL INJURY CAUSED BY ANGIOGRAPHIC CONTRAST-MEDIA

被引：39
作者：
RAININKO, R
机构：
[1] DEPARTMENT OF DIAGNOSTIC RADIOLOGY, TURKU UNIVERSITY HOSPITAL
来源：
ACTA RADIOLOGICA-DIAGNOSIS | 1979年 / 20卷 / 03期
关键词：
D O I：
10.1177/028418517902000302
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The effect of hyperosmolality on the permeability of vascular endothelium was investigated using light microscopy and silver staining of the thoracic aorta in the rat. The threshold osmolality causing significant endothelial injury was 1.41 to 1.59 tested with sodium chloride solutions. The osmolalities of ionic contrast media in clinical concentrations were at or over the osmotic threshold. Most angiographic contrast media injured the endothelium more than equiosmolal sodium chloride solutions. Hyperosmolality is only one factor contributing to the increased endothelial permeability. © 1979, The Foundation Acta Radiologica. All rights reserved.
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页码：410 / 416
页数：7
相关论文
共 13 条
  • [1] OSMOTIC OPENING OF TIGHT JUNCTIONS IN CEREBRAL ENDOTHELIUM
    BRIGHTMAN, MW
    HORI, M
    RAPOPORT, SI
    REESE, TS
    WESTERGAARD, E
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1973, 152 (04) : 317 - 325
  • [2] AN EXPERIMENTAL STUDY OF DISORDERS IN THE PERMEABILITY OF THE CEREBRAL VESSELS (THE BLOOD-BRAIN-BARRIER) PRODUCED BY CHEMICAL AND PHYSICO-CHEMICAL AGENTS
    BROMAN, T
    LINDBERGBROMAN, AM
    [J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1945, 10 (02): : 102 - 125
  • [3] ENDOTHELIAL CELLS AND CEMENT LINES
    FLOREY, HW
    POOLE, JCF
    MEEK, GA
    [J]. JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1959, 77 (02): : 625 - &
  • [4] Harrington G, 1966, Invest Radiol, V1, P431
  • [5] INVITRO AND INVIVO RELEASE OF HISTAMINE BY CONTRAST-MEDIA IN RAT
    LEITE, MP
    MORAES, CRD
    LEME, JG
    [J]. ACTA RADIOLOGICA-DIAGNOSIS, 1975, 16 (02): : 172 - 180
  • [6] MURPHY DJ, 1973, NEUROLOGY, V23, P926, DOI 10.1212/WNL.23.9.926
  • [7] EQUI-OSMOLAL OPENING OF BLOOD-BRAIN-BARRIER IN RABBIT BY DIFFERENT CONTRAST-MEDIA
    RAPOPORT, SI
    THOMPSON, HK
    BIDINGER, JM
    [J]. ACTA RADIOLOGICA-DIAGNOSIS, 1974, 15 (01): : 21 - 32
  • [8] TESTING OF A HYPOTHESIS FOR OSMOTIC OPENING OF BLOOD-BRAIN BARRIER
    RAPOPORT, SI
    HORI, M
    KLATZO, I
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1972, 223 (02): : 323 - +
  • [9] Robinson R. A., 1959, ELECTROLYTE SOLUTION
  • [10] CHANGES IN VASCULAR PERMEABILITY AFTER LOCAL APPLICATION OF ROENTGEN CONTRAST MEDIA IN HAMSTER CHEEK POUCH
    SORENSEN, SE
    [J]. ACTA RADIOLOGICA-DIAGNOSIS, 1971, 11 (03): : 274 - &
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