LIPID MEDIATORS AND PROTEIN-KINASE-C ACTIVATION FOR THE INTRACELLULAR SIGNALING NETWORK

被引：140
|
作者：
NAKAMURA, S [1 ]
NISHIZUKA, Y [1 ]
机构：
[1] KOBE UNIV, BIOSIGNAL RES CTR, NADA KU, KOBE 657, JAPAN
来源：
JOURNAL OF BIOCHEMISTRY | 1994年 / 115卷 / 06期
关键词：
DIACYLGLYCEROL; PHOSPHOLIPASE A(2); PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C;
D O I：
10.1093/oxfordjournals.jbchem.a124451
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Upon stimulation of a cell surface receptor, a membrane phospholipid degradation cascade is often induced through the activation of several phospholipases, yielding various lipid metabolites such as diacylglycerol, free fatty acids, lysophospholipids, and phosphatidic acid. Several isoforms of protein kinase C are each activated distinctly by various combinations of the lipid metabolites, presumably in different subcellular compartments. The pivotal role of this enzyme family in the intracellular signaling network is beginning to emerge.
引用
收藏
页码：1029 / 1034
页数：6
相关论文
共 50 条
  • [1] INTRACELLULAR SIGNALING BY PHOSPHOLIPID HYDROLYSIS AND PROTEIN-KINASE-C ACTIVATION
    ASAOKA, Y
    NAKAMURA, S
    NISHIZUKA, Y
    BIOMEDICAL RESEARCH-TOKYO, 1993, 14 : 93 - 98
  • [2] INTRACELLULAR SIGNALING BY HYDROLYSIS OF PHOSPHOLIPIDS AND ACTIVATION OF PROTEIN-KINASE-C
    NISHIZUKA, Y
    SCIENCE, 1992, 258 (5082) : 607 - 614
  • [3] LIPID ACTIVATION OF PROTEIN-KINASE-C
    BELL, RM
    BURNS, DJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (08) : 4661 - 4664
  • [4] ROLE OF PROTEIN-KINASE-C IN INTRACELLULAR SIGNALING
    HALLER, H
    LINDSCHAU, C
    LUFT, FC
    MOLECULAR AND CELL BIOLOGICAL ASPECTS OF GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR DISEASE, 1994, 733 : 313 - 324
  • [5] ACTIVATION OF PROTEIN-KINASE-C IN LIPID MONOLAYERS
    SOUVIGNET, C
    PELOSIN, JM
    DANIEL, S
    CHAMBAZ, EM
    RANSAC, S
    VERGER, R
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (01) : 40 - 44
  • [6] Phosphatidylcholine hydrolysis and protein kinase C activation for intracellular signaling network
    Nakamura, SI
    JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING, 1996, 14 (1-3): : 197 - 202
  • [7] THE ACTIVATION OF PROTEIN-KINASE-C BY THE LIPID MOIETIES OF LIPOPOLYSACCHARIDE
    WIGHTMAN, PD
    RAETZ, CRH
    FEDERATION PROCEEDINGS, 1986, 45 (03) : 486 - 486
  • [8] TRANSMEMBRANE SIGNALING BY HYDROLYSIS OF PHOSPHOLIPIDS AND ACTIVATION OF PROTEIN-KINASE-C
    NISHIZUKA, Y
    ASAOKA, Y
    NAKAMURA, S
    OGITA, K
    KIKKAWA, U
    SAITO, N
    TANAKA, C
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 20 - 20
  • [9] TRANSMEMBRANE SIGNALING BY HYDROLYSIS OF PHOSPHOLIPIDS AND ACTIVATION OF PROTEIN-KINASE-C
    NISHIZUKA, Y
    ASAOKA, Y
    NAKAMURA, S
    OGITA, K
    KIKKAWA, U
    SAITO, N
    TANAKA, C
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 66 - 66
  • [10] LIPID ACTIVATORS OF PROTEIN-KINASE-C
    CHAUHAN, VPS
    CHAUHAN, A
    DESHMUKH, DS
    BROCKERHOFF, H
    LIFE SCIENCES, 1990, 47 (12) : 981 - 986
12345