POSTERIOR SUBCAPSULAR CATARACTS ASSOCIATED WITH MEGESTROL-ACETATE THERAPY

被引：2

作者：

ARONSON, NE

AMEGIN, GP

机构：

[1] Infectious Disease Service, William Beaumont Army Medical Center, El Paso, Texas

[2] Ophthalmology Service, William Beaumont Army Medical Center, El Paso, Texas

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1993年 / 19卷 / 01期

关键词：

CATARACT; HUMAN IMMUNODEFICIENCY VIRUS; MEGESTROL;

D O I：

10.1016/S0886-3350(13)80290-8

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Megestrol acetate, used for eight weeks as an appetite stimulant in a man infected with human immunodeficiency virus, was associated with the development of bilateral posterior subcapsular cataracts. We propose that the glucocorticoid properties of megestrol were contributory. Complicating this association, the patient developed cytomegalovirus retinitis approximately six weeks after the cataracts were recognized.

引用

页码：90 / 91

页数：2

共 10 条

[1]

Hamburger AW, Parnes H, Gordon GB, Et al., Megestrol acetate-induced differentiation of 3T3-L1 adipocytes in vitro, Semin Oncol, 15, pp. 76-78, (1988)

[2]

Black RL, Oglesby RB, von Sallmann L, Bunim JJ, Posterior subcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis, JAMA, 174, pp. 166-171, (1960)

[3]

Elton RL, Edgren RA, Calhoun DW, Biological activities of some 6-methylated progesterones, Proc Soc Exp Biol Med, 103, pp. 175-177, (1960)

[4]

Briggs MH, Briggs M, Glucocorticoid properties of progestogens, Steroids, 22, pp. 555-559, (1973)

[5]

Aisner J, Tchekmedyian NS, Moody M, Tait N, Highdose megestrol acetate for the treatment of advanced breast cancer: dose and toxicities, Semin Hematol, 24, pp. 48-55, (1987)

[6]

Bonomi P, Pessis D, Bunting N, Et al., Megestrol acetate used as primary hormonal therapy in stage D prostatic cancer, Semin Oncol, 12, pp. 36-39, (1985)

[7]

Nathwani D, Green ST, Heslop JM, Et al., Beneficial response to megoestrol acetate in AIDS-related cachexia and a possible megoestrol withdrawal-associated syndrome?, Acta Derm Venereol (Stockh), 70, pp. 520-521, (1990)

[8]

Bluming AZ, Zeegen P, Cataracts induced by intermittent decadron used as an antiemetic, J Clin Oncol, 4, pp. 221-223, (1986)

[9]

Srinivasan A, Kalyanaraman S, Dutt K, Et al., Isolation of HIV-1 from vitreous humor (letter), Am J Ophthalmol, 108, pp. 197-198, (1989)

[10]

Wong KW, D'Amico DJ, Hedges TR, Et al., Ocular involvement associated with chronic Epstein-Barr virus disease, Arch Ophthalmol, 105, pp. 788-792, (1987)

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