T-CELL T-CELL COLLABORATION IN ALLOGRAFT RESPONSES

被引：18
作者：
GILL, RG
机构：
[1] Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 05期
关键词：
D O I：
10.1016/0952-7915(93)90137-H
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T-cell-T-cell collaboration in allogeneic responses traditionally has been viewed as the requirement for CD4+ T helper cells in the activation of CD8+ cytotoxic T cells. In this regard, the role of the CD4+ T cell is primarily to provide growth factors, such as interleukin-2, on which the CD8+ T cell is dependent. However, expanding information concerning the function of T-cell subsets, and the roles of antigen-presenting cells and cytokines in regulating immune responses, requires that the basic tenets of T-cell interactions be re-evaluated.
引用
收藏
页码：782 / 787
页数：6
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