STUDY ON OXIDATION AND BINDING TO MACROMOLECULES OF THE CARCINOGENIC NON-AMINOAZO DYE 1-PHENYLAZO-2-HYDROXYNAPHTALENE CATALYZED BY HORSERADISH (AMORACIA-RUSTICANA L) PEROXIDASE

被引：9

作者：

STIBOROVA, M ^{[1
]}

FREI, E ^{[1
]}

ANZENBACHER, P ^{[1
]}

机构：

[1] GERMAN CANC RES CTR, INST TOXICOL & CHEMOTHERAPY, W-6900 HEIDELBERG, GERMANY

来源：

BIOCHEMIE UND PHYSIOLOGIE DER PFLANZEN | 1991年 / 187卷 / 03期

关键词：

AZO DYES; MACROMOLECULES; SUDAN-I; XENOBIOTICS METABOLISM IN PLANTS;

D O I：

10.1016/S0015-3796(11)80102-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Horseradish peroxidase-mediated metabolism of carcinogenic 1-phenylazo-2-hydroxynaphthalene (Sudan I) leads to formation of metabolite(s) binding to macromolecules (DNA, tRNA, peroxidase itself) in vitro. The oxidation of Sudan I is a pH-dependent reaction. Not only the amount of Sudan I converted is pH-dependent, but also a different pattern of products is formed. Ascorbate and glutathione inhibit the conversion of Sudan I as well as the binding of metabolite(s) to the peroxidase molecule. The results are discussed from point of view of the metabolism of xenobiotics in plants, which either leads to damages of the plant itself of increases the risk of toxic metabolites entering the trophic chains.

引用

页码：227 / 236

页数：10

共 33 条

[1] Anders MW, 1985, BIOACTIVATION FOREIG
[2] ASFAW B, 1988, INT S BIOCH CHEM CAR, P1
[3] CYTOCHROME-P-450-DEPENDENT METABOLISM OF XENOBIOTICS - A COMPARATIVE-STUDY OF RAT HEPATIC AND PLANT MICROSOMAL METABOLISM
BORLAKOGLU, JT
JOHN, P
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 1989, 94 (02): : 613 - 617
[4] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[5] THE SIGNIFICANCE OF AZO-REDUCTION IN THE MUTAGENESIS AND CARCINOGENESIS OF AZO DYES
CHUNG, KT
[J]. MUTATION RESEARCH, 1983, 114 (03): : 269 - 281
[6] OXIDATIVE-METABOLISM OF FOREIGN COMPOUNDS BY HIGHER-PLANTS
DOHN, DR
KRIEGER, RI
[J]. DRUG METABOLISM REVIEWS, 1981, 12 (01) : 119 - 157
[7] N-DEMETHYLATION OF SUBSTITUTED 3-(PHENYL)-1-METHYLUREAS - ISOLATION AND CHARACTERIZATION OF A MICROSOMAL MIXED FUNCTION OXIDASE FROM COTTON
FREAR, DS
SWANSON, HR
TANAKA, FS
[J]. PHYTOCHEMISTRY, 1969, 8 (11) : 2157 - +
[8] INHIBITION OF DIMETHYLNITROSAMINE-INDUCED MUTAGENESIS IN ARABIDOPSIS-THALIANA BY DIETHYLDITHIOCARBAMATE AND CARBON-MONOXIDE
GICHNER, T
VELEMINSKY, J
[J]. MUTATION RESEARCH, 1984, 139 (01): : 29 - 33
[9] ORGANIC-SOLVENTS INHIBIT THE MUTAGENICITY OF PROMUTAGENS DIMETHYLNITROSAMINE AND METHYLBUTYLNITROSAMINE IN A HIGHER-PLANT ARABIDOPSIS-THALIANA
GICHNER, T
VELEMINSKY, J
[J]. MUTAGENESIS, 1986, 1 (02) : 107 - 109
[10] HAMILTON RH, 1971, J AGR FOOD CHEM, V19, P480, DOI 10.1021/jf60175a031

← 1 2 3 4 →