NMR-STUDIES OF INTERACTIONS OF LIGANDS WITH DIHYDROFOLATE-REDUCTASE

被引：27
|
作者：
FEENEY, J
机构：
来源：
BIOCHEMICAL PHARMACOLOGY | 1990年 / 40卷 / 01期
关键词：
correlated spectroscopy; COSY; DHFR; dihydrofolate reductase; HOHAHA; homonuclear Hartmann-Hahn spectroscopy; NOE; nuclear Overhauser effect; RELAY; relayed correlated spectroscopy;
D O I：
10.1016/0006-2952(90)90189-R
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
NMR spectroscopy is a useful technique for studying interactions, conformations and dynamic processes within ligand-protein complexes. Several examples of the application of the method to studies of complexes of anti-folate drugs with their target enzyme, dihydrofolate reductase, are discussed. © 1990.
引用
收藏
页码：141 / 152
页数：12
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