The role of small nuclear RNAs in RNA splicing

被引：23
|
作者：
McKeown, Michael [1 ]
机构：
[1] Salk Inst, Mol Biol & Virol Lab, San Diego, CA 92186 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 03期
关键词：
D O I：
10.1016/0955-0674(93)90010-N
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent genetic and biochemical experiments have revealed an intimate and dynamic role for small nuclear RNAs (snRNAs) in multiple steps of RNA-splicing reactions. Both snRNA substrate and snRNA snRNA interactions are involved. These interactions concern not only splice site and branch point definition, but also the catalytic reactions of the first and second steps of splicing. Studies reveal a striking conservation between snRNA interactions and interactions found in RNAs encoded by genes with group II self-splicing introns.
引用
收藏
页码：448 / 454
页数：7
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